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Association study of sepiapterin reductase gene promoter polymorphisms with schizophrenia in a Han Chinese population

Authors Fu J, Ma G, Mai H, Luo X, Yin J, Chen Q, Lin Z, Tao H, Li Y, Cui L, Li Z, Lin J, Zhao B, Li K

Received 23 July 2015

Accepted for publication 30 September 2015

Published 28 October 2015 Volume 2015:11 Pages 2793—2799

DOI https://doi.org/10.2147/NDT.S92986

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Chin-Pang Lee

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang


Jiawu Fu,1,* Guoda Ma,1,* Hui Mai,1,* Xudong Luo,2 Jingwen Yin,2 Qing Chen,2 Zhixiong Lin,2 Hua Tao,1 You Li,1 Lili Cui,1 Zheng Li,3 Juda Lin,2 Bin Zhao,1 Keshen Li1

1Institute of Neurology, Affiliated Hospital of Guangdong Medical University, 2Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang, People’s Republic of China; 3Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA

*These authors contributed equally to this work

Abstract: Sepiapterin reductase participates in the biosynthesis of tetrahydrobiopterin, which plays very important roles in the pathogenesis of schizophrenia via dysregulation of ­neurotransmitter systems. Here, two single nucleotide polymorphisms (rs1876487 and rs2421095) in the promoter region of SPR were genotyped in 941 schizophrenic patients and 944 controls in a Han Chinese population using the SNaPshot technique. No significant differences were found in the distribution of alleles or genotypes of the two single nucleotide polymorphisms (SNPs) between schizophrenic patients and controls (all P>0.05). Likewise, no haplotype was found to be associated with schizophrenia. However, sex-stratified analysis revealed that the frequencies of the A allele of rs1876487 and the A–A (rs2421095–rs1876487) haplotype were all significantly different between schizophrenia and controls in females (P=0.040 and P=0.033, respectively), but not in males. Additionally, luciferase reporter gene assays revealed that the A–A haplotype had significantly higher SPR transcriptional activity compared with the A–C haplotype in SH-SY5Y cells. Our data indicate that the two SNPs do not influence the risk of schizophrenia when using the total sample, but the A allele of rs1876487 and the A–A haplotype may contribute to protective roles for schizophrenia in females.

Keywords: schizophrenia, sepiapterin reductase, polymorphisms, Han Chinese population, transcriptional activity

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