Association of serum procalcitonin and C-reactive protein levels with CURB-65 criteria among patients with community-acquired pneumonia
Received 10 February 2018
Accepted for publication 5 April 2018
Published 13 June 2018 Volume 2018:11 Pages 217—223
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Colin Mak
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Fariba Keramat,1,2 Hamid Reza Ghasemi Basir,3 Elham Abdoli,2 Arghavan Shafiei Aghdam,4 Jalal Poorolajal5
1Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Infectious Diseases, Sina Hospital, Hamadan University of Medical Sciences, Hamadan, Iran; 3Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 4School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 5Research Center for Health Sciences, Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran
Background: The concentration of diagnostic markers such as inflammatory biomarkers including procalcitonin (PCT) and C-reactive protein (CRP) increases in bacterial infections. The aim of this study was to compare serum PCT and CRP levels with CURB-65 ranking, in the patients with community-acquired pneumonia (CAP).
Patients and methods: In a cross-sectional study, 93 hospitalized patients with a definite diagnosis of CAP, considering inclusion and exclusion criteria, were enrolled. Serum PCT and CRP levels and their relations with CURB-65 criteria were assessed.
Results: The mean serum levels of PCT and CRP were 3.64±12.32 ng/mL and 75.01±51.93 mg/L, respectively. There was a statistically significant association between CURB-65 criteria and serum levels of PCT (P=0.0001) and CRP (P=0.007), which means that the concentration of these two inflammatory biomarkers increased with an increase in the score of CURB-65 criteria. Moreover, there was a statistically significant association between the serum level of PCT and the outcomes of the disease (P<0.001).
Conclusion: According to the results, the serum level of PCT or CRP is a strong prognostic factor for evaluating severity of CAP and is a suitable factor for the CURB-65 criteria in the decision making of whether a patient with CAP in the ICU should be admitted.
Keywords: procalcitonin, community-acquired pneumonia, C-reactive protein, CURB-65
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