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Association of prostate volume with incidence and aggressiveness of prostate cancer

Authors Al-Khalil S, Ibilibor C, Cammack JT, de Riese W

Received 23 July 2016

Accepted for publication 10 September 2016

Published 26 October 2016 Volume 2016:8 Pages 201—205

DOI https://doi.org/10.2147/RRU.S117963

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr Jan Colli


Shadi Al-Khalil, Christine Ibilibor, James Thomas Cammack, Werner de Riese

Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA

Objective: The aim of this study was to investigate the possible correlation between prostate volume and aggressiveness and incidence of prostate cancer (PCa).
Patients and methods: A chart review of a cohort of 448 consecutive prostate biopsy-naive men was performed. These men underwent at least a 12-core biopsy at our institution due to increased prostate-specific antigen serum levels (>4 ng/mL) and/or suspicious findings on digital rectal examination during the period between 2008 and 2013. Transrectal ultrasound was used to determine the prostate volume.
Results: The positive biopsy rate was 66% for patients with a prostate volume of ≤35 cc and 40% for patients with a prostate volume of ≥65 cc (P<0.001). Of the 110 patients testing positive on biopsy with a volume of ≤35 cc, 10 patients (9.1%) had a Gleason score of ≥8. Of the 27 patients testing positive on biopsy with a volume of ≥65 cc, only 1 patient (3.7%) had a Gleason score of ≥8.
Conclusion: These results suggest that there may be an association between prostate volume and the incidence and aggressiveness of PCa. The larger the prostate, the lower the positive biopsy rate for PCa and the lower the Gleason score.

Keywords: prostate cancer, prostate-specific antigen, prostate volume

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