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Association of polymorphisms in WWOX gene with risk and outcome of osteosarcoma in a sample of the young Chinese population

Authors Zhang N, Ye Z, Ren W, Yuan L, Zhu Y

Received 25 October 2015

Accepted for publication 24 December 2015

Published 19 February 2016 Volume 2016:9 Pages 807—813


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Professor Daniele Santini

Niannian Zhang,1 Zhenghui Jiang,2,3 Weifeng Ren,1 Li Yuan,4 Yangyi Zhu1

1Department of Orthopedics, Shaoxing Shangyu People’s Hospital, Shaoxing, People’s Republic of China; 2Division of Musculoskeletal Oncology, Department of Orthopedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 3Department of Orthopedics, The First People’s Hospital of Wenling, Wenling, People’s Republic of China; 4Department of Epidemiology, School of Public Health, Fudan University, Shanghai, People’s Republic of China

Abstract: The WW domain-containing oxidoreductase (WWOX) gene is a tumor suppressor gene, the abnormal expression of which will lead to osteosarcoma tumorigenesis. Polymorphisms of the WWOX gene are associated with the risk of several malignancies. We hypothesized that genetic variations in the WWOX gene were related to osteosarcoma risk and outcome. In this case-control study, we recruited 276 young osteosarcoma patients and 286 controls from the East Chinese population and genotyped seven tag single-nucleotide polymorphisms (SNPs) of the WWOX gene (rs10220974C>T, rs12918952G>A, rs3764340C>G, rs1074963C>G, rs383362G>T, rs1424110A>G, and rs12828A>G). We discovered that two SNPs (rs3764340C>G and rs383362G>T) were associated with osteosarcoma risk. The CG genotype and dominant model of rs3764340 indicated elevated risk of osteosarcoma, and similar results were found for rs383362. Furthermore, rs3754340C>G was also related to grade and metastasis risk of osteosarcoma. Taken together, our results provide the first evidence that WWOX gene polymorphisms have the potential to be predictive factors for assessing risk and outcome of osteosarcoma.

osteosarcoma, WWOX, SNP, metastasis, susceptibility

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