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Association of HLA alleles with autism

Authors Sayad A, Akbari MT, Noroozi R, Omrani MD, Inoko H, Taheri M, Ghafouri-Fard S

Received 6 September 2018

Accepted for publication 8 November 2018

Published 27 November 2018 Volume 2018:14 Pages 3259—3265

DOI https://doi.org/10.2147/NDT.S186673

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Arezou Sayad,1 Mohammad Taghi Akbari,2 Rezvan Noroozi,3 Mir Davood Omrani,1,4 Hidetoshi Inoko,5 Mohammad Taheri,6 Soudeh Ghafouri-Fard1

1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; 3Photochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 5Department of Molecular Life Science, Tokai University, Hiratsuka, Japan; 6Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background:
Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental disorders known by impaired social interaction and activities and abnormal repetitive behavior. As a multifactorial disorder, several genetic and immunological factors have been shown to be implicated in its pathogenesis.
Methods: Among them are certain human leukocyte antigen (HLA) alleles. In the current study, we genotyped HLA-A, -B & DRB alleles in 103 Iranian ASD patients and 180 age, gender, and ethnic-matched healthy controls.
Results: After Boferroni correction no allele or haplotype was associated with genetic susceptibility to ASD in Iranian population.
Conclusion: Future studies are needed to assess contribution of immunological factors such as HLA alleles in ASD pathogenesis.

Keywords: autism, HLA typing, immune response

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