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Association Of GSTM1, GSTT1 And GSTP1 Polymorphisms With Breast Cancer Among Jordanian Women

Authors AL-Eitan LN, Rababa'h DM, Alghamdi MA, Khasawneh RH

Received 1 March 2019

Accepted for publication 10 September 2019

Published 20 September 2019 Volume 2019:12 Pages 7757—7765

DOI https://doi.org/10.2147/OTT.S207255

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Aruna Narula

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati


Laith N AL-Eitan,1,2 Doaa M Rababa’h,1 Mansour A Alghamdi,3 Rame H Khasawneh4

1Department of Applied Biological Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan; 2Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan; 3Department of Anatomy, College of Medicine, King Khalid University, Abha, Saudi Arabia; 4Department of Hematopathology, King Hussein Medical Center (KHMC), Jordanian Royal Medical Services (RMS), Amman 11118, Jordan

Correspondence: Laith N AL-Eitan
Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
Tel +962-2-7201000 Ext 23464
Fax +962-2-7201071
Email lneitan@just.edu.jo

Purpose: Genetic predisposition to disease has become one of the most investigated risk factors in recent years, and breast cancer (BC) is no exception. In this study, we investigated specific genetic variants of three candidate genes belonging to the glutathione-S-transferase superfamily that have been implicated in increased risk of cancers.
Materials and methods: This case-control study comprised 241 Jordanian women who were diagnosed with BC in addition to 219 matched controls. Gel electrophoresis of PCR products was used to visualize and genotype both the GSTM1 and GSTT1 genes, while PCR-RFLP was employed to genotype the rs1695 of the GSTP1 gene.
Results: Our findings did not reveal any correlation between the investigated polymorphisms of GST genes and BC risk among Jordanian women. Otherwise, the combination of GSTM1 entire gene deletion and (GG) genotype of GSTP1 polymorphism (rs1695) was significantly associated with BC with p-value <0.05 (i.e. p-value was not significant after correcting for multiple comparison).
Conclusion: We suggest that the interaction between GSTM1 polymorphism and rs1695 of GSTP1 may influence BC development and progression among Jordanian women. More epidemiological studies are needed to provide a baseline for the underlying role of GSTs polymorphisms in tumorigenesis.

Keywords: breast, cancer, genetic variation, GST genes, polymorphisms


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