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Association between WWOX and the risk of malignant tumor, especially among Asians: evidence from a meta-analysis

Authors Yuan H, Wu Y, Zhang J, Shi G, Liu D, He Y, Lu Z, Wu P, Jiang K, Miao Y

Received 20 September 2017

Accepted for publication 28 November 2017

Published 3 April 2018 Volume 2018:11 Pages 1801—1811

DOI https://doi.org/10.2147/OTT.S152140

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Samir Farghaly


Hao Yuan,1,2,* Yang Wu,1,2,* Jingjing Zhang,1,2 Guodong Shi,1,2 Dongfang Liu,1,2 Yuan He1,2 Zipeng Lu,1,2 Pengfei Wu,1,2 Kuirong Jiang,1,2 Yi Miao1,2

1Pancreas Center, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 2Pancreas Institute, Nanjing Medical University, Nanjing, People’s Republic of China

*These authors contributed equally to this work

Purpose: Many studies have been carried out to examine whether there are associations between WWOX polymorphisms (rs3764340 C>G, rs12918952 G>A, and rs383362 G>T) and malignant tumor risk, but the results from these studies remained inconsistent and even controversial. In the present study, we performed a meta-analysis to evaluate the relationships comprehensively.
Methods: Published reports were searched in PubMed, Google Scholar, and Chinese National Knowledge Infrastructure databases. Eight eligible case–control studies were included in the final analysis. In the analysis, pooled odds ratios (ORs) with corresponding 95% CIs were calculated in five genetic models to assess the genetic risk. Egger’s regression and Begg’s funnel plots test were conducted to appraise the publication bias.
Results: We found that rs12918952 G>A and rs383362 G>T polymorphisms were not associated with the susceptibility of malignant tumor. However, a significant correlation was found between WWOX rs3764340 C>G and malignant tumor risk in three genetic models (CG vs CC: OR=1.31, 95% CI: 1.12–1.53, P=0.031; GG/CG vs CC: OR=1.31, 95% CI: 1.11–1.54, P=0.014; G vs C: OR=1.28, 95% CI: 1.09–1.50, P=0.009). Furthermore, when stratified by source of control, the results were significant especially in population-based control for rs3764340.
Conclusion: In general, our results first indicated that the rs3764340 C>G polymorphism in WWOX gene can increase the susceptibility of tumor, while the others cannot. However, large, well-designed epidemiological studies are required to verify our findings.

Keywords: malignant tumor, WWOX, meta-analysis, polymorphism, susceptibility

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