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Association between potentially functional polymorphisms of chemokine family members and the survival of esophageal cancer patients in a Chinese population

Authors Du JL, Li GN, He RW, Zhang SZ, Zhang X, Huang ZG

Received 26 October 2018

Accepted for publication 26 April 2019

Published 13 June 2019 Volume 2019:12 Pages 4631—4641

DOI https://doi.org/10.2147/OTT.S192362

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


Jin-Lin Du,1 Ge-Nan Li,2 Rong-Wei He,1 Shi-Zhuo Zhang,1 Xing Zhang,1 Zhi-Gang Huang1

1Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, 523808, People’s Republic of China; 2Department of Hospital Nutrition, First Affiliated Hospital of PLA General Hospital, Beijing, 100048, People’s Republic of China

Background: The chemokine family plays an important role in the growth, invasion, and metastasis of tumors. However, most studies have only focused on a few genes or a few gene loci, and thus could not reveal the associations between functional polymorphisms of chemokine family members and tumor progression. This study aimed to determine the associations between single nucleotide polymorphisms (SNPs) of chemokine family members and the prognosis of esophageal cancer (EC).
Methods: The Cox risk proportional model and log-rank test were used to analyze the associations of 16 potentially functional SNPs in 13 genes from the chemokine family with the survival of 729 Chinese patients with EC.
Results: Prognostic analysis on the 16 SNPs showed that different genotypes of 5 SNPs were associated with patients’ survival and the risk of death. Multivariate Cox regression analysis showed that the risk of death was higher in CCL26rs2302009 genotype A/C carriers than in A/A carriers and it was also higher in CX3CL1rs2239352 genotype T/T carriers than in C/C carriers. Stepwise Cox regression analysis showed that CCL26rs2302009 genotype A/C was an independent prognostic factor of EC, and its association with increased risk of death was stronger in patients who were ≤60 years old, female, with tumors located in the middle part of esophagus, with undifferentiated or poorly differentiated tumors, with early-stage pathologic type disease, with the longest diameter of tumor ≤5cm than in their counterparts.
Conclusion: These findings suggest that CCL26rs2302009 may be a candidate biomarker for EC and its effect on death risk are associated with the histological grade, pathologic type, and the longest diameter of tumor.

Keywords: esophageal cancer, prognosis, single nucleotide polymorphism, chemotactic factor

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