Association Between Hemoglobin and Growth Hormone Peak in Chinese Children and Adolescents with Short Stature: A Cross-Sectional Study
Authors Zhang T, Ban B, Zhang M, Ji B, Sun H, Sun B
Received 19 November 2020
Accepted for publication 25 January 2021
Published 16 February 2021 Volume 2021:14 Pages 497—504
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Tian Zhang,1 Bo Ban,2,3 Mei Zhang,2,3 Baolan Ji,2,3 Hailing Sun,2,3 Bing Sun1
1Department of Clinical Medicine, Jining Medical University, Jining, Shandong, People’s Republic of China; 2Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, People’s Republic of China; 3Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong, People’s Republic of China
Correspondence: Bing Sun
Department of Clinical Medicine, Jining Medical University, 16 Hehua Road, Beihu New District, Jining, Shandong, People’s Republic of China
Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, People’s Republic of China
Objective: This research aimed to investigate the relationship between hemoglobin (Hb) and growth hormone (GH) peak in children and adolescents with short stature.
Design: This cross-sectional study included a total of 787 children and adolescents with short stature. Anthropometric and biochemical indicators were measured at baseline. All patients underwent GH provocation tests with L-dopa and insulin to assess GH peak levels.
Results: The univariate analysis results showed that Hb was positively associated with GH peak (β 0.07, P=0.001). Furthermore, a non-linear relationship was detected between Hb and GH peaks through smooth curve fitting, and the inflection point was 123 g/L after multivariate piecewise linear regression analysis. GH peak increased with Hb elevation when the Hb level was greater than 123 g/L (β 0.08, 95% CI 0.01, 0.14; P=0.0207).
Conclusion: In children and adolescents with short stature, we found GH peak was positively associated with the Hb level when the Hb level reached the inflection point.
Keywords: hemoglobin, growth hormone peak, short stature
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