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Association Between Hemoglobin and Growth Hormone Peak in Chinese Children and Adolescents with Short Stature: A Cross-Sectional Study

Authors Zhang T, Ban B, Zhang M, Ji B, Sun H, Sun B

Received 19 November 2020

Accepted for publication 25 January 2021

Published 16 February 2021 Volume 2021:14 Pages 497—504

DOI https://doi.org/10.2147/IJGM.S292920

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Tian Zhang,1 Bo Ban,2,3 Mei Zhang,2,3 Baolan Ji,2,3 Hailing Sun,2,3 Bing Sun1

1Department of Clinical Medicine, Jining Medical University, Jining, Shandong, People’s Republic of China; 2Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, People’s Republic of China; 3Chinese Research Center for Behavior Medicine in Growth and Development, Jining, Shandong, People’s Republic of China

Correspondence: Bing Sun
Department of Clinical Medicine, Jining Medical University, 16 Hehua Road, Beihu New District, Jining, Shandong, People’s Republic of China
Email sdsunb@163.com
Hailing Sun
Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining, 272029, Shandong, People’s Republic of China
Email sunhailingjn@163.com

Objective: This research aimed to investigate the relationship between hemoglobin (Hb) and growth hormone (GH) peak in children and adolescents with short stature.
Design: This cross-sectional study included a total of 787 children and adolescents with short stature. Anthropometric and biochemical indicators were measured at baseline. All patients underwent GH provocation tests with L-dopa and insulin to assess GH peak levels.
Results: The univariate analysis results showed that Hb was positively associated with GH peak (β 0.07, P=0.001). Furthermore, a non-linear relationship was detected between Hb and GH peaks through smooth curve fitting, and the inflection point was 123 g/L after multivariate piecewise linear regression analysis. GH peak increased with Hb elevation when the Hb level was greater than 123 g/L (β 0.08, 95% CI 0.01, 0.14; P=0.0207).
Conclusion: In children and adolescents with short stature, we found GH peak was positively associated with the Hb level when the Hb level reached the inflection point.

Keywords: hemoglobin, growth hormone peak, short stature

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