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Association Between Gastric Lymphoid Follicles (Precursor Of MALT Lymphomas) And H. pylori Infection At A Referral Hospital In Iran

Authors Bashiri H, Esmaeilzadeh A, Vossoughinia H, Ghaffarzadegan K, Raziei HR, Bozorgomid A

Received 26 July 2019

Accepted for publication 10 October 2019

Published 29 October 2019 Volume 2019:12 Pages 409—413

DOI https://doi.org/10.2147/CEG.S224823

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Koulaouzidis


Homayoon Bashiri,1,2 Abbas Esmaeilzadeh,3 Hassan Vossoughinia,3 Kamran Ghaffarzadegan,4 Hamid Reza Raziei,5 Arezoo Bozorgomid1

1Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Department of Internal Medicine, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; 3Gastroenterology and Hematology Department, Faculty of Medicine, Ghaem Hospital, Mashhad, Iran; 4Pathology Department, Education and Research Department, Razavi Hospital, Mashhad, Iran; 5Department of Oncology and Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence: Arezoo Bozorgomid
Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Tel +98 918 872 8269
Email arezoobozorgomid@yahoo.com

Purpose: Mucosa-associated lymphoid tissue (MALT) is the most common endoscopic finding in Helicobacter pylori positive patients that can progress to MALT lymphoma after a prolonged antigenic contact. This study was aimed to evaluate the prevalence of lymphoid follicles and aggregates (precursors of MALT lymphomas) in gastric mucosal biopsies and their correlation with H. pylori infection.
Patients and methods: In this study, 100 patients who had undergone an upper gastrointestinal endoscopy were enrolled. Five biopsy specimens were taken each patient through screening endoscopy and histopathological changes were evaluated and graded using the Wotherspoon System. The clinical background and H. pylori infection status were also investigated.
Results: Among the 100 cases in our series, 79 patients (79%) showed evidence of MALT in at least one biopsy specimen taken from the stomach and 21 cases (21%) had no evidence of MALT. H. pylori infection was detected in 74 (74%) patients. Lymphoid follicles were detected more frequently in H. pylori-positive patients (59%) compared to H. pylori-negative cases (3%) (P<0.001).
Conclusion: The frequency of lymphoid follicles and aggregates in gastric mucosal is associated with H. pylori infection. Further community-based studies in larger sample sizes using a combination of microscopic methods and PCR assay are required for effective monitoring of H. pylori infection.

Keywords: gastritis, Helicobacter pylori, lymphoid aggregate, lymphoid follicle

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