Back to Journals » Clinical Interventions in Aging » Volume 15

Association Between Bone Mineral Density and Lipid Profile in Chinese Women

Authors Zhang Q, Zhou J, Wang Q, Lu C, Xu Y, Cao H, Xie X, Wu X, Li J, Chen D

Received 8 June 2020

Accepted for publication 11 August 2020

Published 15 September 2020 Volume 2020:15 Pages 1649—1664

DOI https://doi.org/10.2147/CIA.S266722

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Zhi-Ying Wu


Qi Zhang,1,* Junteng Zhou,2,* Qin Wang,1 Chunyan Lu,1 Yong Xu,3 Hongyi Cao,4 Xiaohua Xie,5 Xueyan Wu,6 Jing Li,1 Decai Chen1

1Sichuan University West China Hospital, Department of Endocrinology and Metabolism, Chengdu, Sichuan 610041, People’s Republic of China; 2Sichuan University West China Hospital, Department of Cardiology, Chengdu, Sichuan 610041, People’s Republic of China; 3Affiliated Hospital of Southwest Medical University, Department of Endocrinology and Metabolism, Luzhou, Sichuan 646000, People’s Republic of China; 4Chengdu Fifth People’s Hospital, Department of Endocrinology and Metabolism, Chengdu, Sichuan 610041, People’s Republic of China; 5The First People’s Hospital of Liangshan Prefecture, Department of Endocrinology and Metabolism, Liangshan, Sichuan 615000, People’s Republic of China; 6Guangyuan Central Hospital, Department of Endocrinology and Metabolism, Guangyuan, Sichuan 628099, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Decai Chen
Sichuan University West China Hospital, Department of Endocrinology and Metabolism, Chengdu, Sichuan 610041, People’s Republic of China
Tel +86 2885422982
Email cdc1309@163.com

Purpose: Atherosclerotic cardiovascular disease may share the risk factors for low bone mineral density (BMD), one of which is dyslipidemia. The association between serum cholesterol and BMD remains controversial. Thus, the correlation between serum lipids and BMD in women was explored in the current study.
Materials and Methods: This cross-sectional study included 1116 Chinese female participants. Serum samples were collected to evaluate total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and other laboratory markers. Dual-energy X-ray absorptiometry was used to assess lumbar spine, femoral neck, and total hip BMD.
Results: In the postmenopausal women, a non-linear relationship was detected between TC, LDL-C, HDL-C, and lumbar spine BMD. Using segmented linear regression, the inflection points were 5.86 mmol/L, 3.52 mmol/L, and 2.37 mmol/L, respectively. To the left of the inflection point, the higher the serum lipid level, the lower the value for lumbar spine BMD. To the right of the inflection point, the higher the serum level of TC and LDL-C, the higher the value for lumbar spine BMD. In the premenopausal women, the association between HDL-C and femoral neck BMD was non-linear. In addition, LDL-C had a positive association with BMD of the femoral neck and HDL-C had an inverse association with BMD of the femoral neck in postmenopausal women.
Conclusion: In postmenopausal women, the relationship between TC, LDL-C, HDL-C, and lumbar spine BMD was non-linear. TC, LDL-C, and HDL-C were negatively associated with lumbar spine BMD when the values were less than 5.86 mmol/L, 3.52 mmol/L, and 2.37 mmol/L, respectively. The mechanisms of the association were unclear, and further research is warranted to clarify the relationship.

Keywords: serum lipids, bone mineral density, postmenopausal women, premenopausal women, cholesterol

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]