Association Between Body Composition and Frailty in Elder Inpatients
Authors Xu L, Zhang J, Shen S, Hong X, Zeng X, Yang Y, Liu Z, Chen L, Chen X
Received 20 December 2019
Accepted for publication 6 February 2020
Published 4 March 2020 Volume 2020:15 Pages 313—320
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Zhi-Ying Wu
Liyu Xu,1 Jie Zhang,2 Shanshan Shen,1 Xiufang Hong,1 Xingkun Zeng,1 Yinghong Yang,1 Zixia Liu,1 Lingyan Chen,1 Xujiao Chen1
1Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, People’s Republic of China; 2Department of Dentistry, Zhejiang Hospital, Hangzhou 310013, People’s Republic of China
Correspondence: Xujiao Chen
Department of Geriatrics, Zhejiang Hospital, Lingyin Road #12, Hangzhou 310013, People’s Republic of China
Tel +86 18069897567
Fax +86 0571 87985100
Purpose: The study aimed to investigate the association between body composition and frailty in elder inpatients.
Patients and Methods: This is a cross-sectional study including 656 elder inpatients (275 females and 381 males) aged ≥ 65 years, from department of geriatrics of Zhejiang Hospital between January 2018 and March 2019. Sociodemographic, health-related data and anthropometric measurements were evaluated. Body composition was assessed by bioimpedance analysis (BIA), mainly including skeletal muscle mass, body fat mass, total body water, fat-free mass,percent body fat, basal metabolic rate. Frailty was assessed by Clinical Frailty Scale (CFS). Univariate logistic regression was used to analyze the association between body composition and frailty.
Results: Frailty was present in 43.9% of the participants. Frail inpatients showed higher waist circumference, body fat mass and percent body fat, non-frail inpatients showed greater upper arm circumference, calf circumference, skeletal muscle mass, total body water, fat-free mass and basal metabolic rate. Subjects with underweight (body mass index (BMI)< 18.5 kg/m2; odds ratio (OR), 95% confidence interval (CI)=4.146 (1.286– 13.368) P=0.017) and those with high waist circumference (OR 95% CI=1.428 (0.584– 3.491) P< 0.001), body fat mass (OR, 95% CI=1.143 (0.892– 1.315) P< 0.001) presented a higher risk of frailty compared to normal subjects. Skeletal muscle mass (OR; 95% CI=0.159 (0.064– 0.396) P< 0.001) was a protective factor for frailty.
Conclusion: Frailty in elder Chinese inpatients was characterized by a body composition phenotype with underweight, high waist circumference, low skeletal muscle mass and high body fat mass. Underweight, abdominal obesity and sarcopenic obesity may, therefore, be targets for intervention of frailty.
Keywords: frailty, elderly, skeletal muscle mass, body fat mass
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]