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Association between apolipoprotein E gene polymorphism and mild cognitive impairment: a meta-analysis

Authors Jiang Y, He T, Deng W, Sun P

Received 10 June 2017

Accepted for publication 8 October 2017

Published 13 November 2017 Volume 2017:12 Pages 1941—1949

DOI https://doi.org/10.2147/CIA.S143632

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Wu


Yunxia Jiang,1,* Tao He,2,* Wenshuai Deng,2 Peng Sun2

1Nursing College of Qingdao University, Qingdao University, 2Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, China

*These authors contributed equally to this work

Abstract: A number of published case–control studies reported that the apolipoprotein E (ApoE) gene polymorphism was associated with the mild cognitive impairment (MCI). However, previous reports still remain conflicting. To estimate the association between ApoE polymorphism and MCI susceptibility, we searched the electronic databases including PubMed, Wanfang, CNKI (China National Knowledge Infrastructure), VIP, and EMBASE to retrieve all available studies. A total of 18 studies with 2,004 cases and 3,705 controls were included in this meta-analysis. The pooled analysis based on selected studies showed that statistically significant risk association was found between ApoE gene polymorphism and MCI in overall population (ε4 vs ε3: odds ratio [OR] =2.38, 95% confidence interval [CI]: 2.11–2.68; ε4/ε4 vs ε3/ε3: OR =4.45, 95% CI: 3.06–6.48; ε2/ε4 vs ε3/ε3: OR =2.57, 95% CI: 1.77–3.73; ε3/ε4 vs ε3/ε3: OR =2.31, 95% CI: 1.99–2.69). However, no significant association was detected in two genetic models: ε2 versus ε3 (OR =0.90, 95% CI: 0.77–1.05) and ε2/ε2 versus ε3/ε3 (OR =0.91, 95% CI: 0.50–1.65). Furthermore, ApoE ε2/ε3 genotype provided a slight protection for MCI in overall population (ε2/ε3 vs ε3/ε3: OR =0.80, 95% CI: 0.66–0.97). In the stratified analysis based on ethnicity, similar results were also observed in Chinese population (significant risk: ε4 vs ε3: OR =2.52, 95% CI: 2.19–2.90; ε4/ε4 vs ε3/ε3: OR =5.45, 95% CI: 3.41–8.70; ε2/ε4 vs ε3/ε3: OR =2.59, 95% CI: 1.74–3.86; ε3/ε4 vs ε3/ε3: OR =2.34, 95% CI: 1.97–2.79; slight protection: ε2/ε3 vs ε3/ε3: OR =0.79, 95% CI: 0.64–0.98; no association: ε2 vs ε3: OR =0.92, 95% CI: 0.78–1.09; and ε2/ε2 vs ε3/ε3: OR =1.04, 95% CI: 0.55–1.99). In summary, this meta-analysis of 5,709 subjects suggested that ApoE ε4 allele was associated with an increased risk of MCI. In addition, ApoE ε2/ε3 genotype provided a slight protection for MCI.

Keywords: mild cognitive impairment, apolipoprotein E, polymorphism, meta-analysis

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