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Associated depression in pseudophakic patients with intraocular lens with and without chromophore

Authors Mendoza Mendieta ME, Lorenzo-Mejía AA

Received 26 August 2015

Accepted for publication 8 February 2016

Published 31 March 2016 Volume 2016:10 Pages 577—581


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

María Elena Mendoza-Mendieta, Ana Aurora Lorenzo-Mejía

Association to Prevent Blindness in Mexico (APEC), Hospital “Dr Luis Sánchez Bulnes”, Mexico City, Mexico

Background: With aging, the crystalline lens turns yellowish, which increases the absorption of wavelengths in the blue electromagnetic spectrum, reducing their photoreception in the retina. Since these wavelengths are the main stimulus in the regulation of the circadian rhythm, progressive reduction in their transmission is associated with chronic sleep disturbances and depression in elderly patients. Cataract extraction improves circadian photoreception at any age. However, lenses that block blue waves have 27% to 38% less melatonin suppression than lenses that block only ultraviolet (UV) rays.
Purpose: To assess the depression symptoms in subjects who have had bilateral phacoemulsification and intraocular lens (IOL) implants, one group with yellow chromophore IOLs and the other group with transparent IOLs were compared.
Setting: Association to Prevent Blindness in Mexico (APEC), Hospital “Dr Luis Sánchez Bulnes”.
This was an observational, cross-sectional, and single-center study.
Materials and methods:
Twenty-six subjects between 60 and 80 years of age, with a history of bilateral phacoemulsification and placement of the same type of IOL in both eyes from 4 to 12 months prior to the study, who attended the follow-up visits and agreed to participate in this study, and provided signed informed consent were included in the study. They were asked to answer the short version of the 15-item Geriatric Depression Scale.
The average age of the study participants was 72.5±5.94 years. The group without chromophore included 46.1% (n=12) of the patients and the group with chromophore included 53.9% (n=14) of the patients (P=0.088).
Conclusion: In the group of patients with IOLs that block the passage of blue light, the depression rate was 21.4%, a rate similar to that observed in the elderly population, whereas no patients in the group with transparent IOLs had depression.

cataract, depression, intraocular lens, chromophore

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