Back to Journals » International Journal of General Medicine » Volume 4

Associated congenital anomalies between neonates with short-gap and long-gap esophageal atresia: a comparative study

Authors Aslanabadi S, Ghabili K, Rouzrokh M, Hosseini MB, Jamshidi M, Adl FH, Shoja MM

Published 23 June 2011 Volume 2011:4 Pages 487—491


Review by Single-blind

Peer reviewer comments 4

Saeid Aslanabadi1, Kamyar Ghabili2, Mohsen Rouzrokh3, Mohammad Bagher Hosseini1, Masoud Jamshidi1, Farzad Hami Adl4, Mohammadali M Shoja5
1Pediatric Health Research Center, Tabriz University of Medical Sciences, Tabriz; 2Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz; 3Department of Pediatric Surgery, Mofid Hospital, Shaheed Beheshti University of Medical Sciences, Tehran; 4Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz; 5Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Background: Predicting the presence of long-gap esophageal atresia (EA) prior to the surgery is of clinical importance. No comparison between short-gap and long-gap EA for the prevalence of VACTERL and non-VACTERL-type anomalies has yet been performed.
Objective: The aim of this study was to compare VACTERL and non-VACTERL-type anomalies between patients with short-gap and long-gap EA.
Methods: Retrospectively, medical records of all newborns managed for EA/tracheoesophageal fistula (TEF) in Tabriz Children's Hospital and Tehran Mofid Hospital between 2007 and 2010 were evaluated. Demographic data and associated anomalies including both the VACTERL and non-VACTERL-type defects were listed. The VACTERL spectrum defects covered vertebral/costal, anorectal, cardiovascular, TEF, and renal- or radial-type limb anomalies. The non-VACTERL-type anomalies included hydrocephalus, orofacial defects, respiratory system anomalies, gastrointestinal anomalies, genital anomalies, and non-VACTERL limb defects. Demographic data, and the VACTERL and non-VACTERL-type anomalies were compared among children with long-gap EA and those with short-gap EA.
Results: Two hundred and seventy-six children were included in the study: 230 (83.3%) in the short-gap EA group and 46 (16.7%) in the long-gap EA group. Although prevalence of the VACTERL spectrum anomalies did not differ between the two groups, the non-VACTERL anomaly was more common in the long-gap EA group (P = 0.02). Among the VACTERL-type defects, TEF was detected in 30 (65.2%) and 218 (94.7%) patients in long-gap and short-gap EA groups, respectively (P = 0.0001).
Conclusion: The non-VACTERL-type anomalies, but not the VACTERL spectrum defects, are more frequent in patients with long-gap EA than those with short-gap EA.

Keywords: esophageal atresia, short-gap, long-gap, tracheoesophageal fistula, anomaly, VACTERL

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]