Assessment of Microcirculatory Status Based on Stimulation of Myogenic Oscillations by Transient Ischemia: From Health to Disease

Jerzy Gebicki, ^{1, 2} Andrzej Marcinek, ^{1, 2} Jacek Zielinski <sup>3

1</sup>Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, Poland; ²Angionica Ltd, Lodz, Poland; ³Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland

Correspondence: Jerzy Gebicki
Institute of Applied Radiation Chemistry, Lodz University of Technology, Lodz, 90-924, Poland
Tel +48 42 631 3171
Email jerzy.gebicki@p.lodz.pl

The skin is the largest organ of the human body, characterized by exceptional metabolism. The epidermal layer of the skin is not directly vascularized, and oxygen and nutrients are transported from the dermis by diffusion. Therefore, epidermal cell metabolism should be considered a unique and sensitive marker of early dysfunction in vascular circulation and metabolic regulation.
The efforts of the authors of the present contribution have resulted in a new diagnostic technique named Flow Mediated Skin Fluorescence (FMSF), which enables non-invasive evaluation of the vascular circulation and metabolic regulation. ^1,2 The FMSF technique is based on monitoring the intensity of NADH fluorescence from skin tissue on the forearm in response to blocking and releasing blood flow, as a function of time. Measurements are performed using the AngioExpert, a diagnostic device constructed by Angionica Ltd. The FMSF technique has been tested on various pathologies and disorders, as well as in sport physiology. ^{3– 6}