Back to Journals » Clinical Ophthalmology » Volume 7

Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK

Authors Astakhov YS, Astakhov SY, Lisochkina AB, Stolz J

Received 24 June 2013

Accepted for publication 3 August 2013

Published 9 December 2013 Volume 2013:7 Pages 2289—2297


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Yuri S Astakhov, Sergei Y Astakhov, Alla B Lisochkina

University Department of Ophthalmology, State Educational Establishment of Higher Professional Education, Saint Petersburg Pavlov State Medical University and of the Federal Service for Surveillance of Healthcare and Social Development of the Russian Federation, St Petersburg, Russia

Abstract: Laser-assisted in situ keratomileusis (LASIK) is commonly used to correct refractive defects. The procedure frequently results in dry eye symptoms, usually of short but sometimes longer duration. This study was designed to assess dry eye and ocular tolerability after LASIK in patients treated with a preservative-free lacrimal substitute (Hylabak®) or preserved lacrimal substitute (Systane®). In a single-center, investigator-masked, prospective, noninferiority, clinical study, patients undergoing LASIK surgery were randomized to receive Hylabak or Systane eye drops (one drop in each eye four times daily for 3 months). Fluorescein test scores were the primary efficacy variable and were similar on day 1 (mean 0.26 and 0.28 for Hylabak and Systane, respectively). At the final visit (day 84 ± 3) the fluorescein scores had improved to 0.11 and 0.04, respectively. The difference was not significant and thus noninferiority was established. A trend of more rapid improvement in the Hylabak group was evident. Both treatments were well tolerated and there were no serious adverse events, discontinuations for adverse events or other safety-related reasons, and no systemic adverse events. The results suggest that Hylabak is not less effective than Systane in reducing the symptoms of dry eye after LASIK surgery.

Keywords: dry eye, laser-assisted in situ keratomileusis, hyaluronate

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction [Corrigendum]

Muñoz Negrete FJ, Lemij HG, Erb C

Clinical Ophthalmology 2017, 11:887-888

Published Date: 11 May 2017

Switching to preservative-free latanoprost: impact on tolerability and patient satisfaction

Muñoz Negrete FJ, Lemij HG, Erb C

Clinical Ophthalmology 2017, 11:557-566

Published Date: 21 March 2017

Patient satisfaction with glaucoma therapy: reality or myth?

Lemij HG, Hoevenaars JGMM, van der Windt C, Baudouin C

Clinical Ophthalmology 2015, 9:785-793

Published Date: 4 May 2015

A 3-day regimen with azithromycin 1.5% eyedrops for the treatment of purulent bacterial conjunctivitis in children: efficacy on clinical signs and impact on the burden of illness

Bremond-Gignac D, Messaoud R, Lazreg S, Speeg-Schatz C, Renault D, Chiambaretta F

Clinical Ophthalmology 2015, 9:725-732

Published Date: 20 April 2015

A randomized crossover study comparing trehalose/hyaluronate eyedrops and standard treatment: patient satisfaction in the treatment of dry eye syndrome

Pinto-Bonilla JC, del Olmo-Jimeno A, Llovet-Osuna F, Hernández-Galilea E

Therapeutics and Clinical Risk Management 2015, 11:595-603

Published Date: 13 April 2015

European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study

Aslam T, Delcourt C, Holz F, García-Layana A, Leys A, Silva RM, Souied E

Clinical Ophthalmology 2014, 8:2045-2053

Published Date: 10 October 2014

Evaluation of the efficacy, safety, and acceptability of an eyelid warming device for the treatment of meibomian gland dysfunction

Benitez del Castillo JM, Kaercher T, Mansour K, Wylegala E, Dua H

Clinical Ophthalmology 2014, 8:2019-2027

Published Date: 6 October 2014

Latanoprost in the treatment of glaucoma

Alm A

Clinical Ophthalmology 2014, 8:1967-1985

Published Date: 26 September 2014

Use of preservative-free hyaluronic acid (Hylabak®) for a range of patients with dry eye syndrome: experience in Russia

Brzhesky VV, Maychuk YF, Petrayevsky AV, Nagorsky PG

Clinical Ophthalmology 2014, 8:1169-1177

Published Date: 18 June 2014

Topical azithromycin or ofloxacin for endophthalmitis prophylaxis after intravitreal injection

Romero-Aroca P, Sararols L, Arias L, Casaroli-Marano RP, Bassaganyas F

Clinical Ophthalmology 2012, 6:1595-1599

Published Date: 9 October 2012

Tolerability and acceptability of Blephagel: a novel eyelid hygiene aqueous gel

Doan S

Clinical Ophthalmology 2012, 6:71-77

Published Date: 11 January 2012

Do neurologists in Germany adhere to the national Parkinson's disease guideline?

Sabrina Schröder, Daniel Kuessner, Guy Arnold, et al

Neuropsychiatric Disease and Treatment 2011, 7:103-110

Published Date: 7 March 2011

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010