Back to Journals » International Journal of Nanomedicine » Volume 2 » Issue 3

Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats

Authors Efstathios Karathanasis, Rohan Bhavane, Ananth V Annapragada

Published 15 October 2007 Volume 2007:2(3) Pages 501—513

Efstathios Karathanasis1, Rohan Bhavane2, Ananth V Annapragada2

1Chemical Engineering Department, University of Houston, Houston, TX, USA; 2School of Health Informatics, University of Texas Health Science Center, Houston, TX, USA

Abstract: In an attempt to achieve post-inhalation self-regulated insulin release, we constructed a microparticle agglomerate of nano-sized liposomal particles, with the agglomeration facilitated by cross-linkages capable of cleavage by glucose. The particles exhibited a small aerodynamic diameter within the human respirable range, but a large geometric diameter that prevents macrophage uptake and clearance. Upon intratracheal instillation of the “glucose-sensitive” microparticle into the lungs of rats, hyperglycemic events triggered an acceleration of the release of insulin achieving normoglycemia shortly after “sensing” the elevated systemic glucose. This work is a demonstration of an inhalable particle with long residence times in the lungs capable of modulating insulin release based on systemic glucose levels.

Keywords: self-regulated release, inhaled insulin, agglomerated vesicle technology, liposomes, glucose sensitive particle

Download Article [PDF] 

Readers of this article also read:

Colloidal stability of carbon nanotubes in an aqueous dispersion of phospholipid

Dionysios Douroumis, Dimitrios G Fatouros, Nikolaos Bouropoulos, Kostas Papagelis, Dimitrios Tasis

International Journal of Nanomedicine 2007, 2:761-766

Published Date: 15 January 2008

Thermal ablation therapeutics based on CNx multi-walled nanotubes

Suzy V Torti, Fiona Byrne, Orla Whelan, Nicole Levi, Burak Ucer

International Journal of Nanomedicine 2007, 2:707-714

Published Date: 15 January 2008

VivaGel™ (SPL7013 Gel): A candidate dendrimer - microbicide for the prevention of HIV and HSV infection

Richard Rupp, Susan L Rosenthal, Lawrence R Stanberry

International Journal of Nanomedicine 2007, 2:561-566

Published Date: 15 January 2008

Nanoparticulate systems for polynucleotide delivery

Ashwin Basarkar, Jagdish Singh

International Journal of Nanomedicine 2007, 2:353-360

Published Date: 15 October 2007

Evaluation of copolymers of N-isopropylacrylamide and 2-dimethyl(aminoethyl)methacrylate in nonviral and adenoviral vectors for gene delivery to nasopharyngeal carcinoma

Jim Moselhy, Swapna Sarkar, Maria C Chia, Joseph D Mocanu, Nicolas Taulier, Fei-Fei Liu, Xiao Yu Wu

International Journal of Nanomedicine 2007, 2:461-478

Published Date: 15 October 2007

Tumor angiogenic endothelial cell targeting by a novel integrin-targeted nanoparticle

Jianwu Xie, Zhimin Shen, King CP Li, Narasimhan Danthi

International Journal of Nanomedicine 2007, 2:479-485

Published Date: 15 October 2007

Associations between the COMT Val/Met polymorphism, early life stress, and personality among healthy adults

Karin F Hoth, Robert H Paul, Leanne M Williams, Carol Dobson-Stone, Elizabeth Todd, Peter R Schofield, John Gunstad, Ronald A Cohen, Evian Gordon

Neuropsychiatric Disease and Treatment 2006, 2:219-225

Published Date: 15 June 2006