Back to Browse Journals » International Journal of Nanomedicine » Volume 2 » Issue 1

Bioconjugated nanoparticle detection of respiratory syncytial virus infection

Authors Ralph A Tripp, Rene Alvarez, Blake Anderson, Les Jones, Craig Weeks, Wei Chen

Published 15 April 2007 Volume 2007:2(1) Pages 117—124

Ralph A Tripp1, Rene Alvarez1, Blake Anderson1, Les Jones1, Craig Weeks1, Wei Chen2

1College of Veterinary Medicine, Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, GA, USA; 2Department of Physics, University of Texas at Arlington, Arlington, TX, USA

Abstract: The integration of nanotechnology with biology has produced major advances in molecular diagnostics, therapeutics, and bioengineering. Recent advances have led to the development of functionalized nanoparticles (NPs) that are covalently linked to biological molecules such as antibodies, peptides, proteins, and nucleic acids. These functionalized NPs allow for development of novel diagnostic tools and methods, particularly for pathogens, as rapid and sensitive diagnostics are essential for defining the emergence of infection, determining the period that preventive measures should be applied, for evaluating drug and vaccine efficacy, and for controlling epidemics. In this study, we show that functionalized NPs conjugated to monoclonal antibodies can be used to rapidly and specifically detect respiratory syncytial virus in vitro and in vivo. These results suggest that functionalized NPs can provide direct, rapid, and sensitive detection of viruses and thereby bridge the gap between current cumbersome virus detection assays and the burgeoning need for more rapid and sensitive detection of viral agents.

Keywords: RSV, virus, nanoparticle, bioconjugated, functionalized

Download Article [PDF] 

Readers of this article also read:

The role of PHD2 mutations in the pathogenesis of erythrocytosis

Gardie B, Percy MJ, Hoogewijs D, Chowdhury R, Bento C, Arsenault PR, Richard S, Almeida H, Ewing J, Lambert F, McMullin MF, Schofield CJ, Lee FS

Hypoxia 2014, 2:71-90

Published Date: 1 July 2014

Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles

Pala K, Serwotka A, Jeleń F, Jakimowicz P, Otlewski J

International Journal of Nanomedicine 2014, 9:67-76

Published Date: 18 December 2013

Visceral obesity is not an independent risk factor of mortality in subjects over 65 years

Thomas F, Pannier B, Benetos A, Vischer UM

Vascular Health and Risk Management 2013, 9:739-745

Published Date: 22 November 2013

Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants

Ma Q, Wang W, Chu PK, Mei S, Ji K, Jin L, Zhang Y,

International Journal of Nanomedicine 2012, 7:1965-1976

Published Date: 17 April 2012

Review of botulinum toxin type A for the prophylactic treatment of chronic daily headache

Stefan Evers

Neuropsychiatric Disease and Treatment 2007, 3:761-764

Published Date: 15 January 2008

Health benefits of Tai Chi for older patients with type 2 diabetes: The “Move It for Diabetes Study” – A randomized controlled trial

Tracey Tsang, Rhonda Orr, Paul Lam, Elizabeth J Comino, Maria Fiatarone Singh

Clinical Interventions in Aging 2007, 2:429-439

Published Date: 15 October 2007

Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder

Bruno Aouizerate, Dominique Guehl, Emmanuel Cuny, Alain Rougier, Pierre Burbaud, Jean Tignol, Bernard Bioulac

Neuropsychiatric Disease and Treatment 2005, 1:231-243

Published Date: 15 October 2005