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Relationship of glucose-6-phosphate dehydrogenase deficiency and neonatal sepsis: a single-center investigation on the major cause of neonatal morbidity and mortality

Authors Zekavat OR, Makarem A, Bahrami R, Dastgheib N, Dehghani SJ

Received 21 January 2019

Accepted for publication 20 March 2019

Published 11 April 2019 Volume 2019:10 Pages 33—37

DOI https://doi.org/10.2147/PHMT.S202080

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr Roosy Aulakh


Omid Reza Zekavat,1 Alireza Makarem,2 Reza Bahrami,3 Niloofar Dastgheib,4 Seyed Javad Dehghani5

1Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran; 3Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 4Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran; 5Neshat Laboratory Research Center, Shiraz, Iran

Introduction: Neonatal sepsis is a serious disease with distinct clinical and laboratory findings. G6PD deficiency is known as the most common human erythrocyte-enzyme deficiency. This study was designed to investigate the relationship between G6PD deficiency and neonatal sepsis, since it is a major cause of neonatal morbidity and mortality.
Methods: A cross-sectional case–control study was designed and performed on 50 neonates who had been admitted to the neonatal intensive-care unit and diagnosed with sepsis and 50 normal neonate controls. Quantitative G6PD-enzyme activity was assessed in the case and control groups.
Results: Quantitative G6PD-level assessment showed that five (5%) subjects in the case group vs one (1%) of the control group were severely deficient and nine (9%) cases vs one (1%) control were moderately deficient. Enzyme-level differences were statistically significant (P=0.003).
Conclusion: Our study showed higher incidence of G6PD deficiency in neonates who had been admitted due to sepsis. We suggest quantitative G6PD-level assessment instead of the routine qualitative methods in prevalent G6PD deficiency. It is also recommended that neonates with G6PD deficiency be under close supervision during the first month of life, especially those with other risks of neonatal sepsis, such as prematurity or low birth weight.

Keywords: G6PD, neonatal sepsis, morbidity


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