Back to Browse Journals » International Journal of Women's Health » Volume 2

Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions

Authors Deirdre R Pachman, Jason M Jones, Charles L Loprinzi

Published Date May 2010 Volume 2010:2 Pages 123—135

DOI http://dx.doi.org/10.2147/IJWH.S7721

Published 14 May 2010

Deirdre R Pachman1, Jason M Jones1, Charles L Loprinzi2

1Internal Medicine, Mayo Clinic, Rochester, MN, USA; 2Medical Oncology, Mayo Clinic, Rochester, MN, USA

Abstract: Hot flashes are one of the most common and distressing symptoms associated with menopause, occurring in more than 75% of postmenopausal women. They are especially problematic in breast cancer patients since some breast cancer therapies can induce hot flashes. For mild hot flashes, it is proposed that behavioral modifications are the first step in management. Hormonal therapies, including estrogens and progestogens, are the most well known effective agents in relieving hot flashes; however, the safety of these agents is controversial. There is an increasing amount of literature on nonhormonal agents for the treatment of hot flashes. The most promising data regard newer antidepressant agents such as venlafaxine, which reduces hot flashes by about 60%. Gabapentin is another nonhormonal agent that is effective in reducing hot flashes. While many complimentary therapies, including phytoestrogens, black cohosh, and dehydroepiandrosterone, have been explored for the treatment of hot flashes; none can be recommended at this time. Furthermore, there is a lack of strong evidence to support exercise, yoga, or relaxation for the treatment of hot flashes. Paced respirations and hypnosis appear to be promising enough to warrant further investigation. Another promising nonpharmacological therapy, currently under investigation, involves a stellate ganglion block.
Keywords: vasomotor symptoms, hot flashes, menopause, therapy

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Readers of this article also read:

Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid

Nanda SS, An SS, Yi DK

International Journal of Nanomedicine 2015, 10:549-556

Published Date: 12 January 2015

Sigma-1 receptor concentration in plasma of patients with late-life depression: a preliminary study

Shimizu H, Takebayashi M, Tani M, Tanaka H, Yamagata B, Kurosawa K, Yamada H, Hachisu M, Hisaoka-Nakashima K, Okada-Tsuchioka M, Mimura M, Iwanami A

Neuropsychiatric Disease and Treatment 2013, 9:1867-1872

Published Date: 6 December 2013

Effectiveness of preventive home visits in reducing the risk of falls in old age: a randomized controlled trial

Luck T, Motzek T, Luppa M, Matschinger H, Fleischer S, Sesselmann Y, Roling G, Beutner K, König HH, Behrens J, Riedel-Heller SG

Clinical Interventions in Aging 2013, 8:697-702

Published Date: 12 June 2013

Bimatoprost ophthalmic solution 0.03% lowered intraocular pressure of normal-tension glaucoma with minimal adverse events. [Corrigendum]

Tsumura T, Yoshikawa K, Suzumura H, Kimura T, Sasaki S, Kimura I, Takeda R

Clinical Ophthalmology 2013, 7:129-130

Published Date: 16 January 2013

Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells

Kanmogne GD, Singh S, Roy U, Liu X, McMillan J, Gorantla S, Balkundi S, Smith N, Alnouti Y, Gautam N, Zhou Y, Poluektova L, Kabanov A, Bronich T, Gendelman HE

International Journal of Nanomedicine 2012, 7:2373-2388

Published Date: 8 May 2012

Bone integration capability of nanopolymorphic crystalline hydroxyapatite coated on titanium implants

Yamada M, Ueno T, Tsukimura N, Ikeda T, Nakagawa K, Hori N, Suzuki T, Ogawa T

International Journal of Nanomedicine 2012, 7:859-873

Published Date: 17 February 2012

An analysis of the Bateson Review of research using nonhuman primates

Greek R, Hansen LA, Menache A

Medicolegal and Bioethics 2011, 1:3-22

Published Date: 6 December 2011

Physician participation in clinical research and trials: issues and approaches

Sayeeda Rahman, Md Anwarul Azim Majumder, Sami F Shaban, et al

Advances in Medical Education and Practice 2011, 2:85-93

Published Date: 7 March 2011