Back to Browse Journals » Clinical Ophthalmology » Volume 2 » Issue 1

Ligneous conjunctivitis in a patient with Crohn′s disease

Authors Graciana Fuentes-Páez, José M Herreras, M del C Méndez, MA Saorni

Published 7 March 2008 Volume 2008:2(1) Pages 203—206

DOI http://dx.doi.org/10.2147/OPTH.S2215

Graciana Fuentes-Páez1, José M Herreras1, M del C Méndez2, MA Saorni1,2

1Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain and Hospital Universitario de Valladolid, Spain; 2Ocular Pathology and Lab Registry “Miguel N. Burnier”, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain

Objective: Report the case of a patient with Crohn´s disease and ligneous conjunctivitis.

Methods: Interventional case report of a 27-year old female patient, with a 4-year history of Crohn´s disease, was seen for right eye conjunctival ulcer after resolved chemical trauma. Conjunctival biopsy was performed for histopathology, immunofluorescence microscopy, and immunohistochemistry testing.

Results: Microbiology tests were negative for bacteria and fungi. PCR was negative for atypical mycobacteria and Herpes. Ocular Crohn´s disease, Whipple disease, and amyloidosis were ruled out. Immunofluorescence microscopy revealed characteristic IgG κ and λ light chain deposits, and fibrin deposition was confirmed through Lendrum´s Martius, Scarlet, and Blue technique. Endogenous plasminogen levels were normal. Recurrent ulcers did not resolve after treatment with infliximab, but only after four surgeries, topical steroids, 1% cyclosporine, heparin (5000 units/ml), and hyaluronidase (1.5 mg/ml). After 9 months of follow-up, nasal symblepharon was observed as sequela.

Conclusions: We report the case of a patient with unilateral ligneous conjunctivitis, triggered by chemical injury, and Crohn´s disease.

Keywords: Crohn´s disease, immunofluorescence microscopy, ligneous conjunctivitis, plasminogen, ulcerative conjunctivitis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

Proliferation and stemness preservation of human adipose-derived stem cells by surface-modified in situ TiO2 nanofibrous surfaces

Tan AW, Tay L, Chua KH, Ahmad R, Ali Akbar S, Pingguan-Murphy B

International Journal of Nanomedicine 2014, 9:5389-5401

Published Date: 21 November 2014

Cross-linked polyethylenimine–tripolyphosphate nanoparticles for gene delivery

Huang XZ, Shen SJ, Zhang ZF, Zhuang JH

International Journal of Nanomedicine 2014, 9:4785-4794

Published Date: 16 October 2014

Prevalence of drug resistance and culture-positive rate among microorganisms isolated from patients with ocular infections over a 4-year period

Shimizu Y, Toshida H, Honda R, Matsui A, Ohta T, Asada Y, Murakami A

Clinical Ophthalmology 2013, 7:695-702

Published Date: 9 April 2013

Therapeutic effect of bortezomib for primary plasma cell leukemia followed by auto/allo stem cell transplantation

Ozasa R, Hotta M, Yoshimura H, Nakanishi T, Tamaki T, Fujita S, Nakamichi N, Miyaji M, Ishii K, Ito T, Nomura S

International Medical Case Reports Journal 2012, 5:39-43

Published Date: 6 July 2012

Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy

Inoue K, Fujimoto T, Higa R, Moriyama R, Kohmoto H, Nagumo H, Wakakura M, Tomita G

Clinical Ophthalmology 2012, 6:771-775

Published Date: 21 May 2012

Role of phosphodiesterase 5 in synaptic plasticity and memory

Daniela Puzzo, Salvatore Sapienza, Ottavio Arancio, Agostino Palmeri

Neuropsychiatric Disease and Treatment 2008, 4:371-387

Published Date: 11 April 2008

An intractable case of Pseudomonas aeruginosa infection after scleral buckling for rhegmatogenous retinal detachment

Nami Nishikiori, Hiroshi Ohguro

Clinical Ophthalmology 2008, 2:223-225

Published Date: 7 March 2008

Long-time visual functional results of cataract surgery on low vision patients

Eva I Mönestam, Britta M Lundqvist, Åsa C Jonsson

Clinical Ophthalmology 2008, 2:187-194

Published Date: 7 March 2008