Back to Browse Journals » Neuropsychiatric Disease and Treatment » Volume 5

Coenzyme Q10 effects in neurodegenerative disease

Authors Meredith Spindler, M Flint Beal, Claire Henchcliffe

Published 9 November 2009 Volume 2009:5 Pages 597—610


Review by Single-blind

Peer reviewer comments 5

Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,2

1Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USA

Abstract: Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress. Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes, Huntington’s disease, Alzheimer disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis, with equivocal findings. CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.

Keywords: coenzyme Q10, neurodegenerative disease, Parkinson’s disease, Huntington’s disease, mitochondrial dysfunction

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Other articles by this author:

Rasagiline in treatment of Parkinson’s disease

Lakshmi Nayak, Claire Henchcliffe

Neuropsychiatric Disease and Treatment 2008, 4:11-20

Published Date: 8 February 2008

Readers of this article also read:

Advance care planning in stroke: influence of time on engagement in the process

Green T, Gandhi S, Kleissen T, Simon J, Raffin-Bouchal S, Ryckborst K

Patient Preference and Adherence 2014, 8:119-126

Published Date: 24 January 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Particle size reduction to the nanometer range: a promising approach to improve buccal absorption of poorly water-soluble drugs

Rao S, Song Y, Peddie F, Evans AM

International Journal of Nanomedicine 2011, 6:1245-1251

Published Date: 20 June 2011

The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia

Rivka Yatuv, Micah Robinson, Inbal Dayan-Tarshish, et al

International Journal of Nanomedicine 2010, 5:581-591

Published Date: 6 August 2010

Patient preference for needleless factor VIII reconstitution device: the Italian experience

Roberto Musso, Rita Santoro, Antonio Coppola, et al

International Journal of General Medicine 2010, 3:203-208

Published Date: 8 July 2010

Burden of diabetes in the adult Chinese population: A systematic literature review and future projections

Changyu Pan, Shuhua Shang, Wilhelm Kirch, et al

International Journal of General Medicine 2010, 3:173-179

Published Date: 22 June 2010