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Steroid-resistant nephrotic syndrome: past and current perspectives

Authors Nourbakhsh N, Mak RH

Received 16 September 2016

Accepted for publication 18 November 2016

Published 11 April 2017 Volume 2017:8 Pages 29—37

DOI https://doi.org/10.2147/PHMT.S100803

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Roosy Aulakh

Noureddin Nourbakhsh, Robert H Mak

Division of Pediatric Nephrology, Rady Children’s Hospital San Diego, University of California, San Diego, La Jolla, CA, USA

Abstract: Patients with steroid-resistant nephrotic syndrome (SRNS) represent a challenging subset of patients with nephrotic syndrome who often fail standard immunosuppression and have a higher likelihood of progressing to end-stage renal disease. Appropriate treatment of SRNS requires an adequate understanding of the historical treatment, renal histopathology, and genetics associated with the disease. The aim of this review is to present a comprehensive appraisal of the history, role of renal biopsy, genetics, and treatment of SRNS.

Keywords: steroid-resistant nephrotic syndrome, focal segmental glomerulosclerosis

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