Back to Browse Journals » Neuropsychiatric Disease and Treatment » Volume 4 » Issue 6

Is schizoaffective disorder a distinct categorical diagnosis? A critical review of the literature

Authors Daniel J Abrams, Donald C Rojas, David B Arciniegas

Published 5 December 2008 Volume 2008:4(6) Pages 1089—1109

DOI http://dx.doi.org/10.2147/NDT.S4120

Review by Single-blind

Peer reviewer comments 2

Daniel J Abrams1, Donald C Rojas1, David B Arciniegas1,2

1Department of Psychiatry; 2Neurobehavioral Disorders Program, Departments of Psychiatry and Neurology, University of Colorado School of Medicine, Denver, CO, USA

Abstract: Considerable debate surrounds the inclusion of schizoaffective disorder in psychiatric nosology. Schizoaffective disorder may be a variant of schizophrenia in which mood symptoms are unusually prominent but not unusual in type. This condition may instead reflect a severe form of either major depressive or bipolar disorder in which episode-related psychotic symptoms fail to remit completely between mood episodes. Alternatively, schizoaffective disorder may reflect the co-occurrence of two relatively common psychiatric illnesses, schizophrenia and a mood disorder (major depressive or bipolar disorder). Each of these formulations of schizoaffective disorder presents nosological challenges because the signs and symptoms of this condition cross conventional categorical diagnostic boundaries between psychotic disorders and mood disorders. The study, evaluation, and treatment of persons presently diagnosed with schizoaffective may be more usefully informed by a dimensional approach. It is in this context that this article reviews and contrasts the categorical and dimensional approaches to its description, neurobiology, and treatment. Based on this review, an argument for the study and treatment of this condition using a dimensional approach is offered.

Keywords: schizoaffective disorder, schizophrenia, bipolar disorder, manic-depressive disorder

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

Integration of multidisciplinary technologies for real time target visualization and verification for radiotherapy

Chang WC, Chen CS, Tai HC, Liu CY, Chen YJ

OncoTargets and Therapy 2014, 7:1143-1150

Published Date: 23 June 2014

Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Li Y, Gobin AM, Dryden GW, Kang X, Xiao D, Li SP, Zhang G, Martin RCG

International Journal of Nanomedicine 2013, 8:2153-2161

Published Date: 18 June 2013

Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models

Sun Z, Yathindranath V, Worden M, Thliveris JA, Chu S, Parkinson FE, Hegmann T, Miller DW

International Journal of Nanomedicine 2013, 8:961-970

Published Date: 7 March 2013

Increased wall thickness using ultrasonography is associated with inflammation in an animal model of experimental colitis

Lied GA, Milde AM, Nylund K, Mujic M, Grimstad T, Hausken T, Gilja OH

Clinical and Experimental Gastroenterology 2012, 5:195-201

Published Date: 2 October 2012

Interaction between submicron COD crystals and renal epithelial cells

Peng H, Ouyang JM, Yao XQ, Yang RE

International Journal of Nanomedicine 2012, 7:4727-4737

Published Date: 29 August 2012

Improving surveillance system and surgical site infection rates through a network: A pilot study from Thailand

Nongyao Kasatpibal, Mette Nørgaard, Silom Jamulitrat

Clinical Epidemiology 2009, 1:67-74

Published Date: 11 May 2009

Review of tenecteplase (TNKase) in the treatment of acute myocardial infarction

Giovanni Melandri, Fabio Vagnarelli, Daniela Calabrese, Franco Semprini, Samuele Nanni, Angelo Branzi

Vascular Health and Risk Management 2009, 5:249-256

Published Date: 26 February 2009

Increased osteoblast cell density on nanostructured PLGA-coated nanostructured titanium for orthopedic applications

Lester J Smith, John S Swaim, Chang Yao, Karen M Haberstroh, Eric A Nauman, Thomas J Webster

International Journal of Nanomedicine 2007, 2:493-499

Published Date: 15 October 2007