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Intravitreal ranibizumab as a primary or a combined treatment for severe retinopathy of prematurity

Authors Arámbulo O, Dib G, Iturralde J, Duran F, Brito M, Filho J

Received 23 June 2015

Accepted for publication 23 September 2015

Published 29 October 2015 Volume 2015:9 Pages 2027—2032

DOI https://doi.org/10.2147/OPTH.S90979

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Yang Liu

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Odalis Arámbulo,1 Gabriel Dib,1 Juan Iturralde,1 Fahir Duran,1 Miguel Brito,1 João B Fortes Filho2

1Department of Ophthalmology, University Hospital of Maracaibo, Maracaibo, Venezuela; 2Department of Ophthalmology, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

Purpose: The aim of the study was to assess the outcomes of severe retinopathy of prematurity (ROP) in zone I or posterior zone II treated with intravitreal ranibizumab (IVR) as monotherapy or combined treatment with laser photocoagulation.
Methods: This is a retrospective study analyzing clinical records of the included patients. Patients were divided into two groups: group 1 included patients who received only IVR treatment; and group 2 was subdivided into group 2A – including patients with IVR as initial treatment and complementary laser photocoagulation if retinal neovascularization or plus disease did not regress, and group 2B – including patients with initial laser photocoagulation and IVR as rescue therapy. Favorable outcomes were regression of the retinal neovascularization and plus disease, meaning control of the disease. Unfavorable outcomes were progression to stages 4 and 5 of ROP.
Results: Fifty-seven eyes were included in the study. Mean birth weight and gestational age were 1,281±254 g and 29.5±2.1 weeks, respectively. Group 1 comprised of 16 eyes, with favorable outcomes in 14 eyes (87.5%). Group 2 comprised of 41 eyes, with favorable outcomes in 29 eyes (70.7%), in a mean follow-up period of 12.8 months.
Conclusion: IVR was effective to treat severe cases of ROP as a primary or a combined treatment. Forty-three of the 57 treated eyes (75.4%) achieved regression of ROP and favorable outcomes.

Keywords: aggressive posterior ROP, bevacizumab, prematurity, ranibizumab, retinopathy of prematurity, therapy, treatment, VEGF

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