Taurine and vitamin E supplementations have minimal effects on body composition, hepatic lipids, and blood hormone and metabolite concentrations in healthy Sprague Dawley rats
Authors Allen P, Brown A, Bohan Brown M, Hsu WH, Beitz DC
Received 20 May 2015
Accepted for publication 13 July 2015
Published 20 October 2015 Volume 2015:7 Pages 77—85
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 4
Editor who approved publication: Dr Chandrika Piyathilake
Portia S Allen,1 Andrew W Brown,2 Michelle M Bohan Brown,3 Walter H Hsu,4 Donald C Beitz1
1Department of Animal Science, Iowa State University, Ames, IA, USA; 2Nutrition Obesity Research Center and Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, USA; 3Department of Biochemistry, Biophysics, and Molecular Biology, 4Department of Biomedical Sciences, Iowa State University, Ames, IA, USA
Background: As prescriptions for off-label pharmaceutical use and autonomous administration of over-the-counter nutraceuticals become mainstream, thorough assessments of these compounds are warranted.
Objective: To determine the effects of gemfibrozil, rosiglitazone, metformin, taurine, and vitamin E on body composition, hepatic lipids, and metabolic hormone and blood metabolite concentrations in a healthy, outbred rat cohort.
Methods: Male Sprague Dawley rats were fed a purified 10 kcal% from fat diet for 56 days and assigned to either the diet alone (control) group or the diet plus oral administration of gemfibrozil (34 mg/kg), metformin (500 mg/kg), rosiglitazone (3 mg/kg), taurine (520 mg/kg), or vitamin E (200 mg/kg) group.
Results: Rosiglitazone administration resulted in a 56% increase in carcass adiposity, cautioning potential prescriptive off-label use. Taurine supplementation had no adverse effects on evaluated parameters. A modest but significant increase in liver triacylglycerol content was observed with vitamin E supplementation compared with control (Δ 17.2 g triacylglycerol/100 g liver lipid).
Conclusion: The evaluated pharmaceuticals had effects in a healthy population similar to the reported effects in their target population, and the nutraceuticals had minimal effects on the measured physiological parameters.
Keywords: thiazolidinedione, gemfibrozil, metformin, animal model
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