Back to Journals » Clinical Interventions in Aging » Volume 3 » Issue 3

Once-yearly zoledronic acid in the prevention of osteoporotic bone fractures in postmenopausal women

Authors Lambrinoudaki I, Vlachou S, Galapi F, Papadimitriou D, Papadias K

Published 12 September 2008 Volume 2008:3(3) Pages 445—451


Irene Lambrinoudaki, Sophia Vlachou, Fotini Galapi, Dimitra Papadimitriou, K Papadias

2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, Greece

Abstract: Zoledronic acid is a nitrogen-containing, third-generation bisphosphonate that has recently been approved for the treatment of postmenopausal osteoporosis as an annual intravenous infusion. Zoledronic acid is an antiresorptive agent which has a high affinity for mineralized bone and especially for sites of high bone turnover. Zoledronic acid is excreted by the kidney without further metabolism. Zoledronic acid administered as a 5 mg intravenous infusion annually increases bone mineral density in the lumbar spine and femoral neck by 6.7% and 5.1% respectively and reduces the incidence of new vertebral and hip fractures by 70% and 41% respectively in postmenopausal women with osteoporosis. Most common side effects are post-dose fever, flu-like symptoms, myalgia, arthralgia, and headache which usually occur in the first 3 days after infusion and are self-limited. Rare adverse effects include renal dysfunction, hypocalcemia, atrial fibrillation, and osteonecrosis of the jaw.

Keywords: zoledronic acid, postmenopausal osteoporosis, bisphosphonate

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Readers of this article also read:

The effect of a virtual ward program on emergency services utilization and quality of life in frail elderly patients after discharge: a pilot study

Leung DYP, Lee DTF, Lee IFK, Lam LW, Lee SWY, Chan MWM, Lam YM, Leung SH, Chiu PC, Ho NKF, Ip MF, Hui MM

Clinical Interventions in Aging 2015, 10:413-420

Published Date: 3 February 2015

Age-related reduction of cerebral ischemic preconditioning: myth or reality?

Della-Morte D, Caciatore F, Salsano E, Pirozzi G, Del Genio MT, D'Antonio I, Gargiulo G, Palmirotta R, Guadagni F, Rundek T, Abete P

Clinical Interventions in Aging 2013, 8:1055-1061

Published Date: 8 August 2013

Diagnostic accuracy of dual-source CT angiography and coronary risk stratification

Xia Yang, Lu-yue Gai, Ping Li, et al

Vascular Health and Risk Management 2010, 6:935-941

Published Date: 14 October 2010

Food effect on the bioavailability of two distinct formulations of megestrol acetate oral suspension

Benoit Deschamps, Naomi Musaji, John A Gillespie

International Journal of Nanomedicine 2009, 4:185-192

Published Date: 2 September 2009

Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole

Subramanian Madhusoodanan, Payal Shah

Clinical Interventions in Aging 2008, 3:491-501

Published Date: 12 September 2008

Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

Shian-ling Ding, Chen-Yang Shen

Clinical Interventions in Aging 2008, 3:431-444

Published Date: 12 September 2008

Effect of multiple impacts on protective properties of external hip protectors

Tatjana Bulat, Shawn Applegarth, Stuart Wilkinson, Shirley G Fitzgerald, Shahbaz Ahmed, Patricia Quigley

Clinical Interventions in Aging 2008, 3:567-571

Published Date: 12 September 2008

Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels

Jutta Dierkes, Claus Luley, Sabine Westphal

Vascular Health and Risk Management 2007, 3:99-108

Published Date: 15 March 2007