Back to Browse Journals » Vascular Health and Risk Management » Volume 4 » Issue 3

Antiplatelet drugs in cardiological practice: Established strategies and new developments

Authors Florian Krötz, Hae-Young Sohn, Volker Klauss

Published 6 June 2008 Volume 2008:4(3) Pages 637—645

DOI http://dx.doi.org/10.2147/VHRM.S2691

Florian Krötz, Hae-Young Sohn, Volker Klauss

Cardiology, Medical Policlinic, Ludwig-Maximilians-Universität, Ziemssenstr. 1, 80336 München

Abstract: A common pathophysiological course in vascular diseases is an overwhelming activation and aggregation of blood platelets, which results in atherothrombosis. By causing the last decisive step of cerebral, coronary, or peripheral arterial ischemia thrombotic complications of atherosclerotic disease represent a major player in death cause statistics of most western countries. The development of novel therapies against platelet-dependent thrombosis and the concurrent improvement of existing therapeutic strategies thus is a paramount focus of pharmaceutical research. Currently, efficiency, dosing and indications of established antiplatelet substances are being re-evaluated, whilst new, so far unrecognized molecular targets for inhibition of platelet activity come up front. This not only allows for interesting new therapeutical options, but also widens our insight into the role platelets play in atherosclerosis in general. This article summarizes the relevant pathophysiology of platelet activation, presents current concepts in antiplatelet drug therapy, and highlights the role of platelets in vascular diseases apart from atherothrombosis.

Keywords: atherothrombosis, antiplatelet drug therapy, pathophysiology, platelet activation

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Readers of this article also read:

Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity

Momic T, Katzhendler J, Shai E, Noy E, Senderowitz H, Eble JA, Marcinkiewicz C, Varon D, Lazarovici P

Drug Design, Development and Therapy 2015, 9:291-304

Published Date: 5 January 2015

Nanopharmaceuticals (part 1): products on the market

Weissig V, Pettinger TK, Murdock N

International Journal of Nanomedicine 2014, 9:4357-4373

Published Date: 15 September 2014

Effective colon cancer prophylaxis in mice using embryonic stem cells and carbon nanotubes

Mocan T, Iancu C

International Journal of Nanomedicine 2011, 6:1945-1954

Published Date: 12 September 2011

Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector

Ebrahim Azizi, Alireza Namazi, Ismaeil Haririan, et al

International Journal of Nanomedicine 2010, 5:455-461

Published Date: 29 June 2010

Isolated spontaneous dissection of the celiac trunk in a patient with bicuspid aortic valve

Abdel-Rauf Zeina, Alicia Nachtigal, Anton Troitsa, et al

Vascular Health and Risk Management 2010, 6:383-386

Published Date: 19 May 2010

The importance of endothelin-1 for microvascular dysfunction in diabetes

Majid Kalani

Vascular Health and Risk Management 2008, 4:1061-1068

Published Date: 10 October 2008

Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Trung D Tran, Shelton D Caruthers, Michael Hughes, John N Marsh, Tillmann Cyrus, et al

International Journal of Nanomedicine 2007, 2:515-526

Published Date: 15 January 2008

Dietary approaches that delay age-related diseases

Arthur V Everitt, Sarah N Hilmer, Jennie C Brand-Miller, Hamish A Jamieson, A Stewart Truswell, Anita P Sharma, Rebecca S Mason, Brian J Morris, David G Le Couteur

Clinical Interventions in Aging 2006, 1:11-31

Published Date: 15 March 2006