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Ewing sarcoma in adolescents and young adults: diagnosis and treatment

Authors Davis LE, Malempati S

Received 28 January 2014

Accepted for publication 16 April 2014

Published 1 September 2014 Volume 2014:4 Pages 21—31

DOI https://doi.org/10.2147/COAYA.S61451

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Lara E Davis,1,2 Suman Malempati2

1Department of Medicine, 2Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA

Abstract: Ewing sarcoma (ES) is a rare tumor that most often occurs in adolescents and young adults. This review discusses the diagnosis, prognosis, and treatment of localized and metastatic ES, with an emphasis on the care of adolescent and young adult patients. The pathobiology is reviewed. Particular attention is given to recent and current clinical trials, and an introduction to future directions for therapy of ES is provided.

Keywords: Ewing, sarcoma, primitive neuroectodermal tumor, PNET

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