Back to Journals » Journal of Inflammation Research » Volume 7

Vitamin D and inflammatory diseases
Authors Yin K, Agrawal D
Received 11 March 2014
Accepted for publication 8 April 2014
Published 29 May 2014 Volume 2014:7 Pages 69—87
DOI https://doi.org/10.2147/JIR.S63898
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Kai Yin, Devendra K Agrawal
Center for Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE, USA
Abstract: Beyond its critical function in calcium homeostasis, vitamin D has recently been found to play an important role in the modulation of the immune/inflammation system via regulating the production of inflammatory cytokines and inhibiting the proliferation of proinflammatory cells, both of which are crucial for the pathogenesis of inflammatory diseases. Several studies have associated lower vitamin D status with increased risk and unfavorable outcome of acute infections. Vitamin D supplementation bolsters clinical responses to acute infection. Moreover, chronic inflammatory diseases, such as atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, nonalcoholic fatty liver disease, and others, tend to have lower vitamin D status, which may play a pleiotropic role in the pathogenesis of the diseases. In this article, we review recent epidemiological and interventional studies of vitamin D in various inflammatory diseases. The potential mechanisms of vitamin D in regulating immune/inflammatory responses in inflammatory diseases are also discussed.
Keywords: asthma, atherosclerosis, chronic kidney disease, inflammatory bowel disease
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.