Back to Browse Journals » Vascular Health and Risk Management » Volume 4 » Issue 2

Vascular risk factors, cognitve decline, and dementia

Authors E Duron, Olivier Hanon

Published 11 April 2008 Volume 2008:4(2) Pages 363—381


E Duron, Olivier Hanon

Broca Hospital, Paris, France

Abstract: Dementia is one of the most important neurological disorders in the elderly. Aging is associated with a large increase in the prevalence and incidence of degenerative (Alzheimer’s disease) and vascular dementia, leading to a devastating loss of autonomy. In view of the increasing longevity of populations worldwide, prevention of dementia has turned into a major public health challenge. In the past decade, several vascular risk factors have been found to be associated with vascular dementia but also Alzheimer’s disease. Some longitudinal studies, have found significant associations between hypertension, diabetus mellitus, and metabolic syndrome, assessed at middle age, and dementia. Studies assessing the link between hypercholesterolemia, atrial fibrillation, smoking, and dementia have given more conflicting results. Furthermore, some studies have highlighted the possible protective effect of antihypertensive therapy on cognition and some trials are evaluating the effects of statins and treatments for insulin resistance. Vascular risk factors and their treatments are a promising avenue of research for prevention of dementia, and further long-term, placebo-controlled, randomized studies, need to be performed.

Keywords: dementia, hypertension, diabetus mellitus, hypercholesterolemia, metabolic syndrome

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:

Readers of this article also read:

Cognitive and psychological profiles in treatment compliance: a study in an elderly population with hemophilia

Riva S, Nobili A, Djade CD, Mancuso ME, Santagostino E, Pravettoni G

Clinical Interventions in Aging 2015, 10:1141-1146

Published Date: 9 July 2015

The influence of age on health valuations: the older olds prefer functional independence while the younger olds prefer less morbidity

Hofman CS, Makai P, Boter H, Buurman BM, de Craen AJ, Olde Rikkert MGM, Donders R, Melis RJF

Clinical Interventions in Aging 2015, 10:1131-1139

Published Date: 8 July 2015

Evaluation of calcified carotid atheroma on panoramic radiographs and Doppler ultrasonography in an older population

Atalay Y, Asutay F, Agacayak KS, Koparal M, Adali F, Gulsun B

Clinical Interventions in Aging 2015, 10:1121-1129

Published Date: 8 July 2015

Prevalence of HIV-related thrombocytopenia among clients at Mbarara Regional Referral Hospital, Mbarara, southwestern Uganda

Taremwa IM, Muyindike WR, Muwanguzi E, Boum II Y, Natukunda B

Journal of Blood Medicine 2015, 6:109-113

Published Date: 10 April 2015

Patient preference and ease of use for different coagulation factor VIII reconstitution device scenarios: a cross-sectional survey in five European countries

Cimino E, Linari S, Malerba M, Halimeh S, Biondo F, Westfeld M

Patient Preference and Adherence 2014, 8:1713-1720

Published Date: 12 December 2014

Near-infrared spectroscopy and plasma homovanillic acid levels in bipolar disorder: a case report

Miura I, Kono S, Oshima S, Kanno-Nozaki K, Mashiko H, Niwa SI, Yabe H

Neuropsychiatric Disease and Treatment 2014, 10:507-511

Published Date: 25 March 2014

The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man

Alessandra Del Fiorentino, Silvana Cianchetti, Alessandro Celi, Giulia Dell’Omo, Roberto Pedrinelli

Vascular Health and Risk Management 2009, 5:233-242

Published Date: 8 February 2009