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Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma

Authors Hu Y, Tan HB, Wang XM, Rong H, Cui HP, Cui H

Received 28 April 2013

Accepted for publication 21 May 2013

Published 31 October 2013 Volume 2013:8 Pages 1467—1470

DOI https://doi.org/10.2147/CIA.S47350

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Ying Hu,1,2 Hai Bo Tan,1 Xin Mei Wang,3 Hua Rong,1 Hong Ping Cui,1 Hao Cui2

Departments of Ophthalmology, 1Shanghai East Hospital of Tongji University, Shanghai, 2First Affiliated Hospital, 3Fourth Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China

Abstract: Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.

Keywords: glaucoma, stem cell, transplantation, cell therapy, aging

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