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5-HTP efficacy and contraindications

Authors Hinz M, Stein A, Uncini T

Received 24 April 2012

Accepted for publication 14 May 2012

Published 19 July 2012 Volume 2012:8 Pages 323—328

DOI https://doi.org/10.2147/NDT.S33259

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Marty Hinz,1 Alvin Stein,2 Thomas Uncini3

1
Clinical Research, NeuroResearch Clinics, Inc, Cape Coral, 2Stein Orthopedic Associates, Plantation, FL, USA; 3University Medical Center Mesabi Hibbing, MN, USA

Abstract: L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of depression and a number of other serotonin-related diseases. These assertions are not supported by the science. Under close examination, 5-HTP may be contraindicated for depression in some of the very patients for whom promoters of 5-HTP advocate its use.

Keywords: 5-HTP, 5-hydroxytryptophan, L-5-HTP, L-5-hydroxytryptophan

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