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Case report

Noteworthy comment: Cyclical Hypereosinophilia, or Gleichs syndrome, a variant of the broader category of Hypereosinophilia Syndrome, may encompass yet other variants as is the situation described in the current case report by Imashuku et al. The time between cycles for the case described had a periodicity longer than those reported previously: three times per year and was FIILI-PDGFRA fusion gene negative. This new variant showed only partial response to treatment with imatinib mesylate (a treatment generally effective in other variants of this syndrome) but did respond to a triad of cyclosporine A, suplatast tosilate and a small dose of prednisolone, over a recent 6 year period. This is a new variant of a rare syndrome not previously described and is indeed noteworthy.

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Effectiveness of a combination of cyclosporine A, suplatast tosilate and prednisolone on periodic oscillating hypereosinophilia

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