Arterial pulmonary hypertension in noncardiac intensive care unit

Mykola V Tsapenko^1,5, Arseniy V Tsapenko², Thomas BO Comfere^3,5, Girish K Mour^1,5, Sunil V Mankad⁴, Ognjen Gajic^1,5

¹Division of Pulmonary and Critical Care Medicine; ³Division of Critical Care Medicine; ⁴Division of Cardiovascular Diseases, Mayo Epidemiology and Translational Research in Intensive Care (M.E.T.R.I.C), Mayo Clinic, Rochester, MN, USA; ²Division of Pulmonary and Critical Care Medicine, Brown University, Miriam Hospital, Providence, RI, USA

Abstract: Pulmonary artery pressure elevation complicates the course of many complex disorders treated in a noncardiac intensive care unit. Acute pulmonary hypertension, however, remains underdiagnosed and its treatment frequently begins only after serious complications have developed. Significant pathophysiologic differences between acute and chronic pulmonary hypertension make current classification and treatment recommendations for chronic pulmonary hypertension barely applicable to acute pulmonary hypertension. In order to clarify the terminology of acute pulmonary hypertension and distinguish it from chronic pulmonary hypertension, we provide a classification of acute pulmonary hypertension according to underlying pathophysiologic mechanisms, clinical features, natural history, and response to treatment. Based on available data, therapy of acute arterial pulmonary hypertension should generally be aimed at acutely relieving right ventricular (RV) pressure overload and preventing RV dysfunction. Cases of severe acute pulmonary hypertension complicated by RV failure and systemic arterial hypotension are real clinical challenges requiring tight hemodynamic monitoring and aggressive treatment including combinations of pulmonary vasodilators, inotropic agents and systemic arterial vasoconstrictors. The choice of vasopressor and inotropes in patients with acute pulmonary hypertension should take into consideration their effects on vascular resistance and cardiac output when used alone or in combinations with other agents, and must be individualized based on patient response.

Keywords: acute pulmonary hypertension, pulmonary hypertension, acute cor pulmonale, cor pulmonale, right heart failure