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Aripiprazole combination for reversal of paliperidone-induced increase in prolactin level

Authors Zhi P, Wang Y, Quan W, Su Y, Zhang H

Received 3 March 2018

Accepted for publication 1 June 2018

Published 27 August 2018 Volume 2018:14 Pages 2175—2179


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang

Pu Zhi,1,* Yanqiong Wang,1,* Wei Quan,1,2 Yanli Su,1 Hui Zhang1

1Department of Psychiatry, Xi’an Mental Health Center, Institute of Mental Health, Xi’an Medical University, Xi’an, China; 2Department of Natural Medicine, Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi’an, China

*These authors contributed equally to this work

Abstract: Hyperprolactinemia is a common side effect of antipsychotic drugs. Although changes of antipsychotic drugs or reduction of their doses can solve this problem, a modification of the treatment regimen can lead to instability in patients. Herein, we followed up a patient with elevated prolactin caused by paliperidone and found that the prolactin level was decreased after the administration of a combination with a low-dose aripiprazole. In addition, we summarized and analyzed the findings from the case and the literature review conducted.

Keywords: aripiprazole, schizophrenia, prolactin

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