Back to Journals » Patient Preference and Adherence » Volume 15

Are Older People Aware of Potential Risks Related to Benzodiazepines They are Taking and Has Anything Changed in Risk Awareness Over Ten Years?

Authors Celikkayalar E, Airaksinen M, Kivelä SL, Nieminen J, Kleme J, Puustinen J

Received 22 September 2020

Accepted for publication 9 December 2020

Published 28 January 2021 Volume 2021:15 Pages 141—147


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen

Ercan Celikkayalar,1 Marja Airaksinen,1 Sirkka-Liisa Kivelä,1,2 Jenni Nieminen,1 Jenni Kleme,1 Juha Puustinen1,3,4

1Clinical Pharmacy Group, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; 2Unit of Family Medicine, Department of Clinical Medicine, Faculty of Medicine, University of Turku, Turku, Finland; 3Social Security Center of Pori, Pori, Finland; 4Unit of Neurology, Satasairaala Central Hospital, Pori, Finland

Correspondence: Ercan Celikkayalar Email

Purpose: The use of benzodiazepines and related drugs (BZD) is common among older adults although there is growing evidence of their harmful effects. This study investigated how well older people are aware of the potential risks related to the BZD they are taking and whether the risk awareness has changed in the years between 2004 and 2015.
Patients and Methods: The data were collected by interviewing BZD using home-dwelling patients aged ≥ 65 years with normal cognitive function (MMSE ≥ 20) who were admitted to the hospital within a 1 month study period in the years 2004 and 2015. Patients were asked whether they were aware of the ten main potential risks related to BZD use. A risk awareness score (range 0– 10) was assessed for each patient, each known potential risk yielding one point.
Results: The study included 37 patients in 2004 and 31 patients in 2015. In 2004, 6/37 patients (16%), while 16/31 patients (52%) in 2015 had risk awareness scores between 6 and 10. Awareness of dependence (p=0.047), interaction with alcohol (p=0.001), dizziness (p=0.002) and developing tolerance (p=0.002) had improved, while awareness of the other potential risks remained unchanged, muscle weakness being the least known (3/37 in 2004 and 4/31 in 2015 were aware of it as a potential risk). Regular BZD use had declined (p=0.043) but pro re nata (PRN; when required) BZD use had increased (p=0.003) between the years 2004 and 2015.
Conclusion: Older BZD users’ awareness of some potential risks related to BZD use (dependence, interaction with alcohol, dizziness and developing tolerance) had improved between 2004 and 2015, while awareness of other potential risks remained unchanged.

Keywords: benzodiazepines, risk awareness, potentially inappropriate medications, insomnia, aged, interview

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]