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Approaches to the Diagnosis and Management of Ovarian Cancer in Pregnancy

Authors Michalczyk K, Cymbaluk-Płoska A

Received 14 November 2020

Accepted for publication 10 February 2021

Published 11 March 2021 Volume 2021:13 Pages 2329—2339

DOI https://doi.org/10.2147/CMAR.S290592

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Editor who approved publication: Dr Seema Singh


Kaja Michalczyk, Aneta Cymbaluk-Płoska

Department of Gynecological Surgery and Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland

Correspondence: Kaja Michalczyk al. Powstańców Wielkopolskich 72, Szczecin, 70-111, Poland
Tel +48 91 466 1332
Fax +48 91 466 1334
Email [email protected]

Abstract: Ovarian cancer is one of the most common gynecological cancers diagnosed in pregnancy. Its management is often very problematic due to the proximity of the adnexa to the developing fetus and chemotherapy-related toxicity risk. Tumor markers and imagining studies play important roles in diagnosis, help differentiate benign masses from malignancy and allow to plan the treatment. Due to the physiological changes that occur in pregnancy, levels of tumor markers can be altered and reduce their diagnostic value. We review current recommendations for the management and treatment of ovarian cancer in pregnant patients considering gestational age at diagnosis, tumor histology, stage of the disease, risk of obstetrical complications, and patient’s preferences.

Keywords: pregnancy, chemotherapy, ovarian malignancy, tumor markers

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