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Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder

Authors Levy F

Received 30 June 2014

Accepted for publication 18 August 2014

Published 6 November 2014 Volume 2014:7 Pages 349—356

DOI https://doi.org/10.2147/PGPM.S52844

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Martin Bluth


Video abstract presented by Florence Levy.

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Florence Levy

School of Psychiatry, University of New South Wales and Prince of Wales Hospital, Sydney, Australia

Abstract: This review examines molecular genetic studies shown to be of importance in the etiology of attention-deficit/hyperactivity disorder (ADHD) and contrasts prefrontal versus subcortical mechanisms. Although these mechanisms are not completely dissociated, an understanding of prefrontal dopaminergic/noradrenergic versus subcortical D1/D2 receptor mechanisms is useful for studies of diagnosis versus potential adverse effects. Dopamine physiology, dopamine receptor studies, alpha-2 agonist studies, and dopamine transporter and potential new therapies are reviewed. Further understandings of molecular mechanisms involved in etiology versus treatment and adverse effects should help personalize the treatment of ADHD.

Keywords: ADHD, dopamine transporter, dopamine receptors, alpha-2 agonists, COMT, stimulant side effects

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