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Application of poly(ethylene glycol)– distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery

Authors Wang R, Xiao R, Zeng Z, Lili Xu, Wang J

Received 31 May 2012

Accepted for publication 25 June 2012

Published 1 August 2012 Volume 2012:7 Pages 4185—4198

DOI https://doi.org/10.2147/IJN.S34489

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Rongrong Wang,1 Renzhong Xiao,2 Zhaowu Zeng,2 Lili Xu,2 Junjie Wang2
1Campus Hospital of Zhejiang University, 2Research Center for Biomedicine and Health, Hangzhou Normal University, Hangzhou, China

Abstract: Poly(ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers are biocompatible and amphiphilic polymers that can be widely utilized in the preparation of liposomes, polymeric nanoparticles, polymer hybrid nanoparticles, solid lipid nanoparticles, lipid–polymer hybrid nanoparticles, and microemulsions. Particularly, the terminal groups of PEG can be activated and linked to various targeting ligands, which can prolong the circulation time, improve the drug bioavailability, reduce undesirable side effects, and especially target specific cells, tissues, and even the intracellular localization in organelles. This review herein aims to describe recent developments in drug carriers exploiting PEG-DSPE block copolymers and their derivatives, and the incorporation of different ligands to the end groups of PEG-DSPE to target delivery, focusing on their modification approaches, advantages, applications, and the probable associated drawbacks.

Keywords: PEG-DSPE, PEG-lipid, Mal-PEG-DSPE, targeting delivery

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