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Application of liposomes in drug development – focus on gastroenterological targets
Authors Zhang J, Wang K, Mao Z, Fan X, Jiang D, Chen M, Cui L, Sun K, Dang S
Received 28 December 2012
Accepted for publication 27 January 2013
Published 8 April 2013 Volume 2013:8(1) Pages 1325—1334
DOI https://doi.org/10.2147/IJN.S42153
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Jian-Xin Zhang,1 Kun Wang,1 Zheng-Fa Mao,1 Xin Fan,1 De-Li Jiang,2 Min Chen,2 Lei Cui,1 Kang Sun,1 Sheng-Chun Dang1
1Department of General Surgery, the Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, People's Republic of China; 2School of Chemistry and Chemical Engineering of Jiangsu University, Zhenjiang, Jiangsu Province, People's Republic of China
Abstract: Over the past decade, liposomes became a focal point in developing drug delivery systems. New liposomes, with novel lipid molecules or conjugates, and new formulations opened possibilities for safely and efficiently treating many diseases including cancers. New types of liposomes can prolong circulation time or specifically deliver drugs to therapeutic targets. This article concentrates on current developments in liposome based drug delivery systems for treating diseases of the gastrointestinal tract. We will review different types and uses of liposomes in the development of therapeutics for gastrointestinal diseases including inflammatory bowel diseases and colorectal cancer.
Keywords: liposome, colorectal cancer, inflammatory bowel disease, drug delivery
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