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Apoptotic membrane dynamics in health and disease

Authors Julian L, Olson M

Received 15 April 2015

Accepted for publication 14 May 2015

Published 14 July 2015 Volume 2015:7 Pages 133—142

DOI https://doi.org/10.2147/CHC.S57893

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Denis Wirtz


Linda Julian, Michael F Olson

Cancer Research UK Beatson Institute, Glasgow, UK

Abstract: Apoptosis, also known as programmed cell death, is a fundamental homeostatic mechanism essential for normal embryonic development and the maintenance of healthy adult tissues. The processes that affect cell membrane dynamics during the tightly regulated apoptotic program have attracted considerable interest over the years. Distinct biochemical and structural alterations to plasma membrane composition and topography contribute to the efficient removal of cellular corpses. In this review, we will discuss these membrane alterations and their importance in maintaining cell and tissue homeostasis.

Keywords: apoptosis, blebbing, membrane dynamics, homeostasis, apoptotic cell clearance

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