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Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease

Authors Chang YP, Chou MC, Lai CL, Chien I, Yang YH

Received 1 March 2019

Accepted for publication 14 May 2019

Published 9 July 2019 Volume 2019:15 Pages 1915—1919

DOI https://doi.org/10.2147/NDT.S207050

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Yu-Ping Ning


Yang-Pei Chang,1 Mei-Chuan Chou,1–3 Chiou-Lian Lai,2,4–5 I Chien,1 Yuan-Han Yang1,2

1Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan; 4Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Background: Extrapyramidal symptoms (EPS) are not uncommon in Alzheimer’s disease (AD). As apolipoprotein E(APOE) e4 allele is a major risk factor for late-onset AD, we intend to examine the association between APOE genotype and the development of EPS in AD.
Method: This study describes two hundred and fifty-five clinically diagnosed AD patients aged 72 to 80 years from 2010 to 2014. We reviewed the medical charts to determine the development of EPS. APOE genotypes were also confirmed.
Results: APOE e4 allele was detected in 74 patients (29%) and rigidity was among the most common EPS (61%). After adjusting the age, gender, baseline clinical dementia rating, we found AD patients carrying APOE e4 allele are more likely to develop EPS (OR: 4.515, p=0.033).
Conclusion: This study demonstrates the higher coexistence of EPS in AD patients with APOE e4 allele. Furthermore, the identification of APOE e4 allele in the development of EPS in AD patients supports the hypothesis that EPS may be partially attributed to AD pathology.

Keywords: Alzheimer’s disease, extrapyramidal symptoms, apolipoprotein e e4

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