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Antiretroviral Therapy-Associated Metabolic Complications: Review of the Recent Studies

Authors Thet D, Siritientong T

Received 3 August 2020

Accepted for publication 3 September 2020

Published 2 October 2020 Volume 2020:12 Pages 507—524

DOI https://doi.org/10.2147/HIV.S275314

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Bassel Sawaya


Daylia Thet, Tippawan Siritientong

Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

Correspondence: Tippawan Siritientong
Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Pathumwan, Bangkok 10330, Thailand
Tel +6661-956-2898
Fax +662-218-8291
Email tippawan.s@pharm.chula.ac.th

Abstract: The extensive utilization of antiretroviral therapy (ART) has successfully improved human immunodeficiency virus (HIV)-associated complications. The incidence of opportunistic infections is decreased by the viral load suppression and the CD4 count promotion. However, metabolic complications, commonly bone demineralization, lipodystrophy, and lactic acidosis, are arising following the adaptation of long-term ART. The events are not drug-specific, but the severity and incidence individually vary depending upon classes of drugs. Such concerning occurrences may lead to discontinuation of current therapy or switching to another regimen with fewer adverse effects. The purpose of this review is to demonstrate the common metabolic abnormalities associated with each class of widely used ART in people living with HIV (PLHIV). Electronic databases such as PubMed, ScienceDirect, Scopus, Google Scholar, SciFinder, and Web of Science were used for the literature search. A better understanding of ART-associated metabolic adverse effects is helpful in various clinical settings so that therapists may optimize treatments in this population.

Keywords: HIV, antiretroviral therapy, lipodystrophy, metabolic, lipid profile

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