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Antioxidant and hepatoprotective effects of Garcinia indica fruit rind in antitubercular drug-induced liver injury in rats

Authors Panda V, Ashar H, Sharan A

Received 7 January 2013

Accepted for publication 25 February 2013

Published 27 March 2013 Volume 2013:3 Pages 29—37

DOI https://doi.org/10.2147/BTAT.S42483

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Vandana S Panda,1 Hardik D Ashar,1 Anita Sharan2

1Department of Pharmacology and Toxicology, Prin KM Kundnani College of Pharmacy, Colaba, Mumbai, India; 2Department of Pathology, Dr DY Patil Medical College, Nerul, Navi Mumbai, India

Abstract: The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) in antitubercular drug (ATD)-induced liver injury were investigated in rats. GIE (400 mg/kg and 800 mg/kg) and the reference drug Liv.52 (500 mg/kg) were administered orally for 29 days to ATD (isoniazid 7.5 mg/kg, rifampicin 10 mg/kg, and pyrazinamide 35 mg/kg)-treated rats. GIE attenuated significantly the ATD-elevated levels of aspartate aminotransferase, alanine transaminase, alkaline phosphatase, bilirubin, and malondialdehyde and restored the ATD-depleted levels of glutathione (GSH), superoxide dismutase, catalase, GSH peroxidase, and GSH reductase. The present findings indicate that the hepatoprotective effect of GIE in ATD-induced oxidative damage may be due to its antioxidant activity.

Keywords: Garcinia indica fruit, antitubercular drugs, Liv.52, hepatoprotective, antioxidant activity

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