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Antibacterial hemostatic dressings with nanoporous bioglass containing silver

Authors Hu G, Xiao L, Tong P, Bi D, Wang H, Ma H, Zhu G, Liu H

Received 21 February 2012

Accepted for publication 21 March 2012

Published 28 May 2012 Volume 2012:7 Pages 2613—2620

DOI https://doi.org/10.2147/IJN.S31081

Review by Single-blind

Peer reviewer comments 4

Gangfeng Hu,1 Luwei Xiao,2 Peijian Tong,2 Dawei Bi,1 Hui Wang,1 Haitao Ma,1 Gang Zhu,1 Hui Liu2
1The First People’s Hospital of Xiaoshan, Hangzhou, China; 2Zhejiang Traditional Chinese Medical University, Hangzhou, China

Abstract: Nanoporous bioglass containing silver (n-BGS) was fabricated using the sol-gel method, with cetyltrimethyl ammonium bromide as template. The results showed that n-BGS with nanoporous structure had a surface area of 467 m2/g and a pore size of around 6 nm, and exhibited a significantly higher water absorption rate compared with BGS without nanopores. The n-BGS containing small amounts of silver (Ag) had a slight effect on its surface area. The n-BGS containing 0.02 wt% Ag, without cytotoxicity, had a good antibacterial effect on Escherichia coli, and its antibacterial rate reached 99% in 12 hours. The n-BGS’s clotting ability significantly decreased prothrombin time (PT) and activated partial thromboplastin time (APTT), indicating n-BGS with a higher surface area could significantly promote blood clotting (by decreasing clotting time) compared with BGS without nanopores. Effective hemostasis was achieved in skin injury models, and bleeding time was reduced. It is suggested that n-BGS could be a good dressing, with antibacterial and hemostatic properties, which might shorten wound bleeding time and control hemorrhage.

Keywords: antibacterial, bioglass, cytotoxicity, dressing, hemostasis, nanopore, silver

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