Back to Journals » Drug Design, Development and Therapy » Volume 15

Antibacterial and Antimicrobial Effects of Xanthorrhizol in the Prevention of Dental Caries: A Systematic Review

Authors Khalid GS, Hamrah MH, Ghafary ES, Hosseini S, Almasi F

Received 24 November 2020

Accepted for publication 20 February 2021

Published 11 March 2021 Volume 2021:15 Pages 1149—1156


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Anastasios Lymperopoulos

Ghulam Sarwar Khalid,1 Mohammad Hassan Hamrah,2 Elaha Somaya Ghafary,3 Sepideh Hosseini,2 Fateme Almasi2

1Department of Pharmacology, Alberoni University, Kapisa, Afghanistan; 2Department of Pediatric Dentistry, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Periodontics, Kabul University of Medical Sciences, Kabul, Afghanistan

Correspondence: Elaha Somaya Ghafary
Department of Periodontics, Kabul Medical University, Kabul, Afghanistan
Tel/Fax +93776665337
Email [email protected]

Background: Xanthorrhizol is one of the numerous phytochemicals whose pharmacological benefits have been explored for its antibacterial and antimicrobial effects. In light of the role bacteria play for initiating tooth decay, this present systematic review assessed xanthorrhizol’s effect against dental caries.
Methods: The electronic databases including Pubmed, Scopus and Embase were searched up to September 2020, Studies examining the antibacterial and antimicrobial effects of xanthorrhizol in the prevention and treatment of dental caries.
Results: Eleven studies met the criteria for final inclusion. Findings from these studies showed that xanthorrhizol showed significant inhibition of notable caries causing bacteria including Streptococcus mutans, Streptococcus sanguinis, Enterococcus faecalis and Bacillus cereus. Furthermore, there was no reported toxicity. However, it could not selectively target the growth of cariogenic bacteria.
Conclusion: So far, studies exploring the use of xanthorrhizol as a potential drug for the prevention and treatment of dental caries have shown promising outcomes. However, more work needs to be done especially in areas such as optimal dose or concentration, in addition, in vitro, in vivo and clinical studies and selective targeting of cariogenic bacteria has been performed.

Keywords: xanthorrhizol, antibacterial, antimicrobial, dental caries

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]