Back to Journals » Cancer Management and Research » Volume 12

Anti-Tumor Activities of Bioactive Phytochemicals in Sophora flavescens for Breast Cancer

Authors Cao X, He Q

Received 20 December 2019

Accepted for publication 5 February 2020

Published 27 February 2020 Volume 2020:12 Pages 1457—1467


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo

Xianjiao Cao, 1 Qingqing He 2

1The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, People’s Republic of China; 2Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, Shandong 250031, People’s Republic of China

Correspondence: Qingqing He
Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force, No. 25 Shifan Road, Jinan, Shandong 250031, People’s Republic of China
Tel +86 13789828035
Fax +86 531666673
Email [email protected]

Abstract: Patients with breast cancer and breast cancer survivors are frequent users of botanicals and their bioactive phytochemicals. In China, active ingredients in Sophora flavescens like matrine (MT), oxymatrine (OMT), other Sophora flavescens alkaloids and Compound Kushen Injection (CKI) are extensively used for multiple malignant tumors. In vivo and in vitro studies have confirmed that these activities or injection have significant effects on relieving symptoms, alleviating side effects after chemotherapy and improving the quality of life of breast cancer patients, where there is evidence for efficacy. A large number of experimental studies have also revealed that they can inhibit the proliferation, invasion and migration of breast cancer cells according to different mechanisms. This provides promising valuable supportive therapies for prevention, treatment and postoperative recovery of breast cancer. Rigorous clinical research and experimental studies reflect integrative care as it is used in hospital is needed to responsibly move this field forward. This review summarizes an up to date knowledge of the available bioactive phytochemicals, their discovery, current clinical and experimental status.

Keywords: breast cancer, Sophora flavescens, CKI, matrine, oxymatrine

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]