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Anti-TNF therapy for juvenile idiopathic arthritis-related uveitis

Authors Semeraro F, Arcidiacono B, Nascimbeni G, Angi M, Parolini B, Costagliola C

Received 8 September 2013

Accepted for publication 12 December 2013

Published 24 March 2014 Volume 2014:8 Pages 341—348

DOI https://doi.org/10.2147/DDDT.S54207

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Francesco Semeraro,1 Barbara Arcidiacono,2 Giuseppe Nascimbeni,1 Martina Angi,1 Barbara Parolini,2 Ciro Costagliola3

1Eye Clinic, Department of Neurological Sciences and Vision, University of Brescia, Brescia, Italy; 2Department of Ophthalmology, S. Anna Hospital, Brescia, Italy; 3Eye Clinic, Department of Health Sciences, University of Molise, Campobasso, Italy

Abstract: Juvenile idiopathic arthritis-related uveitis is the most common type of uveitis in childhood and one of the main causes of visual impairment in children. The introduction of biological treatment has widened the range of therapeutic options for children with uveitis refractory to standard nonbiologic immunosuppressants. Data from clinical trials suggest that both adalimumab and infliximab have demonstrated effectiveness and safety in open-label studies, although no large, randomized, controlled trials have been reported so far. The role of etanercept in treating juvenile idiopathic arthritis-related uveitis is not yet well defined. In our experience, anti-tumor necrosis factor therapy has been shown to be more effective than steroids and/or methotrexate in treating uveitis. Up to now, tumor necrosis factor blocking compounds have been reserved for the treatment of the most severe cases of refractory uveitis, and larger prospective clinical trials are required in order to better assess the safety of these new compounds.

Keywords: adalimumab, etanercept, infliximab

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